ATP6V1A and LSAMP

		ATP6V1A	LSAMP
Description		ATPase H+ transporting V1 subunit A	limbic system associated membrane protein
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Plasma Membrane Microvillus Endosome Membrane Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Transport Vesicle Secretory Granule Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane ATPase Complex	Extracellular Region Cytosol Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding
	Biological Process	Monoatomic Ion Transport Intracellular Iron Ion Homeostasis Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cellular Response To Increased Oxygen Levels Homeostatic Process ATP Metabolic Process Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Cell Adhesion Nervous System Development
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Alendronic acid Etidronic acid Tiludronic acid Bafilomycin A1 Bafilomycin B1
Diseases
GWAS		Prostate cancer ( 23535732)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) BMI x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Emphysema imaging phenotypes ( 26030696) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Itch intensity from mosquito bite adjusted by bite size ( 28199695) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Systemising ( 31508503) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Triglyceride levels ( 34074324)
Interacting Genes		7 interacting genes: ANXA7 CDC42 CDKN1A SMN1 TK1 TUFM UBC	3 interacting genes: NEGR1 NTM PRNP
Entrez ID		523	4045
HPRD ID		06120	09128
Ensembl ID		ENSG00000114573	ENSG00000185565
Uniprot IDs		P38606	B7Z661 Q13449
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?			Side Of Membrane Positive Regulation Of Calcium-mediated Signaling Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Calcium-mediated Signaling ATPase Complex Proton-transporting V-type ATPase, V1 Domain Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Extrinsic Component Of Synaptic Vesicle Membrane Proton-transporting Two-sector ATPase Complex Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V1 Domain Proton-transporting V-type ATPase Complex Intracellular Monoatomic Cation Homeostasis Endosomal Lumen Acidification Chemical Homeostasis Inorganic Ion Homeostasis Homeostatic Process Cellular Response To Increased Oxygen Levels ATP-dependent Protein Binding Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Postsynaptic Density Inclusion Body Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance Negative Regulation Of Interleukin-17 Production Negative Regulation Of Dendritic Spine Maintenance Regulation Of Dendritic Spine Maintenance Extrinsic Component Of Membrane Negative Regulation Of Long-term Synaptic Potentiation Aspartic-type Endopeptidase Inhibitor Activity Intracellular Copper Ion Homeostasis Dendrite Dendritic Spine Maintenance Cuprous Ion Binding Cupric Ion Binding Regulation Of Glutamate Receptor Signaling Pathway Copper Ion Homeostasis Regulation Of Synapse Organization Negative Regulation Of Activated T Cell Proliferation Lamin Binding Type 5 Metabotropic Glutamate Receptor Binding Apical Dendrite Lipid Droplet Formation Positive Regulation Of Saliva Secretion Negative Regulation Of Synapse Organization Positive Regulation Of Digestive System Process Negative Regulation Of Synapse Assembly
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