HIV - New-wiki

Novel	Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
Novel Novel	Symbols LNX1 and MVB12B	Name 1 ligand of numb-protein X 1	Name2 multivesicular body subunit 12B	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols ATG12 and ATG10	Name 1 autophagy related 12	Name2 autophagy related 10	Pathway 1 Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	Pathway 2 Macroautophagy Macroautophagy	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CHMP4A and SYT17	Name 1 charged multivesicular body protein 4A	Name2 synaptotagmin 17	Pathway 1 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CHMP4A and CHMP4C	Name 1 charged multivesicular body protein 4A	Name2 charged multivesicular body protein 4C	Pathway 1 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols PKN1 and UBR2	Name 1 protein kinase N1	Name2 ubiquitin protein ligase E3 component n-recognin 2	Pathway 1 RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Pathway 2 Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols KLF6 and CELSR2	Name 1 KLF transcription factor 6	Name2 cadherin EGF LAG seven-pass G-type receptor 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols CALM2 and KCNQ5	Name 1 calmodulin 2	Name2 potassium voltage-gated channel subfamily Q member 5	Pathway 1 CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Pathway 2 Voltage gated Potassium channels	Drugs 1 Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate	Drugs 2 Enflurane Gabapentin Promethazine Miconazole Ezogabine ICA-105665	Diseases 1	Diseases 2
Novel Novel	Symbols AKR7A2 and AKR7A3	Name 1 aldo-keto reductase family 7 member A2	Name2 aldo-keto reductase family 7 member A3	Pathway 1 Aflatoxin activation and detoxification	Pathway 2 Aflatoxin activation and detoxification	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols SRSF4 and HTATSF1	Name 1 serine and arginine rich splicing factor 4	Name2 HIV-1 Tat specific factor 1	Pathway 1 Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Artenimol	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BUB1 and RAE1	Name 1 BUB1 mitotic checkpoint serine/threonine kinase	Name2 ribonucleic acid export 1	Pathway 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols BNIP3 and RNF24	Name 1 BCL2 interacting protein 3	Name2 ring finger protein 24	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols GJA5 and MARK1	Name 1 gap junction protein alpha 5	Name2 microtubule affinity regulating kinase 1	Pathway 1 Gap junction assembly	Pathway 2	Drugs 1	Drugs 2 Fostamatinib	Diseases 1 Atrial fibrillation	Diseases 2
Novel Novel	Symbols HSPA13 and FRY	Name 1 heat shock protein family A (Hsp70) member 13	Name2 FRY microtubule binding protein	Pathway 1 Regulation of HSF1-mediated heat shock response	Pathway 2	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols NQO2 and IL32	Name 1 N-ribosyldihydronicotinamide:quinone dehydrogenase 2	Name2 interleukin 32	Pathway 1 Phase I - Functionalization of compounds	Pathway 2 Other interleukin signaling RAC3 GTPase cycle	Drugs 1 NADH Menadione Melatonin Primaquine Resveratrol Flavin adenine dinucleotide 10-Propargyl-5,8-Dideazafolic Acid Quercetin Tretazicar (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one Casimiroin	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols OGT and TMCC3	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 transmembrane and coiled-coil domain family 3	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols OGT and CLCC1	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 chloride channel CLIC like 1	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols RAB1A and ADCK1	Name 1 RAB1A, member RAS oncogene family	Name2 aarF domain containing kinase 1	Pathway 1 Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel Novel	Symbols EIF4E and EN2	Name 1 eukaryotic translation initiation factor 4E	Name2 engrailed homeobox 2	Pathway 1 ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Pathway 2	Drugs 1 7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate	Drugs 2 N-cyclohexyltaurine	Diseases 1	Diseases 2
Novel Novel	Symbols POT1 and MICA	Name 1 protection of telomeres 1	Name2 MHC class I polypeptide-related sequence A	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
Novel Novel	Symbols PAXIP1 and CATSPERG	Name 1 PAX interacting protein 1	Name2 catsper channel auxiliary subunit gamma	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Pathway 2 Sperm Motility And Taxes	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols LNX1 and MVB12B	Name 1 ligand of numb-protein X 1	Name2 multivesicular body subunit 12B	Pathway 1 Antigen processing: Ubiquitination & Proteasome degradation	Pathway 2 Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols ATG12 and ATG10	Name 1 autophagy related 12	Name2 autophagy related 10	Pathway 1 Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling	Pathway 2 Macroautophagy Macroautophagy	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CHMP4A and SYT17	Name 1 charged multivesicular body protein 4A	Name2 synaptotagmin 17	Pathway 1 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CHMP4A and CHMP4C	Name 1 charged multivesicular body protein 4A	Name2 charged multivesicular body protein 4C	Pathway 1 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Pathway 2 Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols PKN1 and UBR2	Name 1 protein kinase N1	Name2 ubiquitin protein ligase E3 component n-recognin 2	Pathway 1 RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Pathway 2 Antigen processing: Ubiquitination & Proteasome degradation	Drugs 1 Fostamatinib	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols KLF6 and CELSR2	Name 1 KLF transcription factor 6	Name2 cadherin EGF LAG seven-pass G-type receptor 2	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols CALM2 and KCNQ5	Name 1 calmodulin 2	Name2 potassium voltage-gated channel subfamily Q member 5	Pathway 1 CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	Pathway 2 Voltage gated Potassium channels	Drugs 1 Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate	Drugs 2 Enflurane Gabapentin Promethazine Miconazole Ezogabine ICA-105665	Diseases 1	Diseases 2
Novel	Symbols AKR7A2 and AKR7A3	Name 1 aldo-keto reductase family 7 member A2	Name2 aldo-keto reductase family 7 member A3	Pathway 1 Aflatoxin activation and detoxification	Pathway 2 Aflatoxin activation and detoxification	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols SRSF4 and HTATSF1	Name 1 serine and arginine rich splicing factor 4	Name2 HIV-1 Tat specific factor 1	Pathway 1 Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	Pathway 2 mRNA Splicing - Major Pathway	Drugs 1 Artenimol	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BUB1 and RAE1	Name 1 BUB1 mitotic checkpoint serine/threonine kinase	Name2 ribonucleic acid export 1	Pathway 1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Pathway 2 ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols BNIP3 and RNF24	Name 1 BCL2 interacting protein 3	Name2 ring finger protein 24	Pathway 1	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols GJA5 and MARK1	Name 1 gap junction protein alpha 5	Name2 microtubule affinity regulating kinase 1	Pathway 1 Gap junction assembly	Pathway 2	Drugs 1	Drugs 2 Fostamatinib	Diseases 1 Atrial fibrillation	Diseases 2
Novel	Symbols HSPA13 and FRY	Name 1 heat shock protein family A (Hsp70) member 13	Name2 FRY microtubule binding protein	Pathway 1 Regulation of HSF1-mediated heat shock response	Pathway 2	Drugs 1 Copper	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols NQO2 and IL32	Name 1 N-ribosyldihydronicotinamide:quinone dehydrogenase 2	Name2 interleukin 32	Pathway 1 Phase I - Functionalization of compounds	Pathway 2 Other interleukin signaling RAC3 GTPase cycle	Drugs 1 NADH Menadione Melatonin Primaquine Resveratrol Flavin adenine dinucleotide 10-Propargyl-5,8-Dideazafolic Acid Quercetin Tretazicar (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one Casimiroin	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols OGT and TMCC3	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 transmembrane and coiled-coil domain family 3	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols OGT and CLCC1	Name 1 O-linked N-acetylglucosamine (GlcNAc) transferase	Name2 chloride channel CLIC like 1	Pathway 1 HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols RAB1A and ADCK1	Name 1 RAB1A, member RAS oncogene family	Name2 aarF domain containing kinase 1	Pathway 1 Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Pathway 2	Drugs 1	Drugs 2	Diseases 1	Diseases 2
Novel	Symbols EIF4E and EN2	Name 1 eukaryotic translation initiation factor 4E	Name2 engrailed homeobox 2	Pathway 1 ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Pathway 2	Drugs 1 7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate	Drugs 2 N-cyclohexyltaurine	Diseases 1	Diseases 2
Novel	Symbols POT1 and MICA	Name 1 protection of telomeres 1	Name2 MHC class I polypeptide-related sequence A	Pathway 1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Pathway 2 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Drugs 1	Drugs 2	Diseases 1	Diseases 2 Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
Novel	Symbols PAXIP1 and CATSPERG	Name 1 PAX interacting protein 1	Name2 catsper channel auxiliary subunit gamma	Pathway 1 Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Pathway 2 Sperm Motility And Taxes	Drugs 1	Drugs 2	Diseases 1	Diseases 2

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