MMP7 and MMP1

Number of citations: 0 (PubMedID 7896811)
Data Source: HPRD (in vitro)

		MMP7	MMP1
Name		matrix metallopeptidase 7	matrix metallopeptidase 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Membrane Protein Ectodomain Proteolysis Response To Xenobiotic Stimulus Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV-A
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling
Drugs		Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID	Marimastat CGS-27023 N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases		None	Choriocarcinoma
GWAS		Blood protein levels ( 30072576 ) Night sleep phenotypes ( 27126917 ) Prostate cancer ( 23535732 ) Prostate-specific antigen levels ( 28139693 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 )
Interacting Genes		16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11	17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11
Entrez ID		4316	4312
HPRD ID		01525	00384
Ensembl ID		ENSG00000137673	ENSG00000196611
Uniprot IDs		P09237	B4DN15 P03956 Q53G95
PDB IDs		1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5 7WXX 8JUD 8JUF 8JUG 8K4Z	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
GO Terms Enriched among Interactors		Extracellular Region Extracellular Space Extracellular Matrix Cell Surface Hyaluronic Acid Binding Wound Healing, Spreading Of Cells Extracellular Matrix Disassembly Regulation Of Response To Wounding Cellular Response To UV-A Perineuronal Net Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Lipid Transport Extracellular Matrix Structural Constituent Conferring Compression Resistance Positive Regulation Of Keratinocyte Migration Response To UV-A Positive Regulation Of Bone Resorption Lysosomal Lumen Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endopeptidase Activity Regulation Of Cellular Component Organization Cell Migration Golgi Lumen Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Coagulation Blood Coagulation Protease Binding Peptidase Inhibitor Activity Hemostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Collateral Sprouting System Development Developmental Process Cell Motility Regulation Of Lipid Transport Regulation Of Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Central Nervous System Development Extracellular Matrix Binding Serine-type Endopeptidase Activity Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Positive Regulation Of ERBB Signaling Pathway Regulation Of Bone Resorption Collagen Catabolic Process	Extracellular Space Extracellular Region Extracellular Matrix Myeloid Leukocyte Migration Leukocyte Chemotaxis Hyaluronic Acid Binding Granulocyte Migration Cell Chemotaxis Regulation Of Cell Migration Cell Migration Granulocyte Chemotaxis Cytokine Activity Monocyte Chemotaxis Eosinophil Migration Eosinophil Chemotaxis Regulation Of Cell Motility Leukocyte Migration CCR Chemokine Receptor Binding Cell Motility Regulation Of Locomotion CCR2 Chemokine Receptor Binding Animal Organ Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Chemotaxis Chemokine Activity Positive Regulation Of Locomotion Locomotion Cytokine-mediated Signaling Pathway Perineuronal Net Chemokine-mediated Signaling Pathway Regulation Of Cell Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Homeostatic Process Inflammatory Response Cartilage Development Mononuclear Cell Migration Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Apoptotic Process Regulation Of Lymphocyte Chemotaxis Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Cell Shape Positive Regulation Of Chemotaxis Central Nervous System Development