LATS2 and SUZ12

Number of citations: 54 (PubMedID 27434182)
Data Source: BioGRID (enzymatic study)

		LATS2	SUZ12
Name		large tumor suppressor kinase 2	SUZ12 polycomb repressive complex 2 subunit
Structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Centriolar Satellite	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Chromatin Binding RNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Promoter-specific Chromatin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Oligodendrocyte Differentiation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation
Pathways		Signaling by Hippo	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hip circumference adjusted for BMI ( 34021172 ) Refractive error ( 32231278 )	High chromosomal aberration frequency (chromosome type) ( 31586183 ) Hip circumference adjusted for BMI ( 25673412 )
Interacting Genes		70 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DCAF1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NFIC PDGFRA RAF1 RASSF1 RELA SIAH2 SMAD2 SNAI1 SRC STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YAP1 YWHAG YWHAZ	18 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 RNF10 UBC UBE2I WDR77
Entrez ID		26524	23512
HPRD ID		07277	06949
Ensembl ID		ENSG00000150457	ENSG00000178691
Uniprot IDs		Q9NRM7	J3QQW9 Q15022
PDB IDs		4ZRI	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
GO Terms Enriched among Interactors		Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Kinase Activity Protein Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Signal Transduction Regulation Of Cell Population Proliferation Animal Organ Development Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Growth Factor Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Protein Serine Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition Nucleus Regulation Of Programmed Cell Death Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Protein Phosphorylation Protein Modification Process Regulation Of Protein Modification Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Transferase Activity Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process	Nucleoplasm Protein Modification Process ESC/E(Z) Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein Modification By Small Protein Conjugation Inner Cell Mass Cell Fate Commitment Regulation Of DNA-templated Transcription Initiation Protein-DNA Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process CKM Complex Mediator Complex Regulation Of Developmental Process Post-translational Protein Modification Maintenance Of Cell Number Regulation Of RNA Metabolic Process Transcription Coregulator Activity DNA Replication-dependent Chromatin Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Protein Metabolic Process Transferase Complex Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process G1 To G0 Transition Chromatin Organization Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Chromatin DNA Binding Response To L-glutamate Regulation Of Cell Differentiation Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Elongation Rhythmic Process Nucleosome Assembly