TAP2

Name	transporter 2, ATP binding cassette subfamily B member
Structure
Interactors	10 interactors: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP TMUB1
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Speck Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding Peptide Antigen Binding Metal Ion Binding TAP1 Binding Tapasin Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity
	Biological Process	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport
Pathways	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Diseases	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS	Asthma ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Composite immunoglobulin trait (IgA/IgG) ( 28628107 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) IgA nephropathy ( 25305756 ) Lymphocyte count ( 32888494 ) Lymphoma ( 23349640 ) Nephropathy ( 21399633 ) Platelet distribution width ( 32888494 ) Pubertal anthropometrics ( 23449627 ) Response to hepatitis B vaccine ( 29534301 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Type 1 diabetes (age at diagnosis) ( 33179336 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Urate levels in lean individuals ( 25811787 ) Waist circumference adjusted for body mass index ( 34021172 )
Entrez ID	6891
HPRD ID	01360
Ensembl ID	ENSG00000204267
Uniprot IDs	Q03519 Q5JNW1 Q9UP03 X5CMH5
PDB IDs	5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J
GO Terms Enriched among Interactors ?	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen Phagocytic Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane TAP2 Binding TAP1 Binding MHC Class I Peptide Loading Complex MHC Class I Protein Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Proteasome Core Complex, Beta-subunit Complex Protein-containing Complex Assembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Proteasome Assembly Protein Trimerization Protein-containing Complex Organization MHC Class I Protein Binding Proteasome Core Complex Early Endosome Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of T Cell Mediated Cytotoxicity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Proteasome Complex MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity External Side Of Plasma Membrane Cellular Component Assembly Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle