NLGN2

Name	neuroligin 2
Structure
Novel Interactors	1 novel interactors: DNAH9
Interactors	8 interactors: DLG2 DLG3 DLG4 MDGA1 NRXN1 NRXN2 NRXN3 PATJ
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Axon Dendrite Presynaptic Membrane Cell Projection Dendritic Shaft Synapse Postsynaptic Membrane Excitatory Synapse Inhibitory Synapse Ribbon Synapse Glycinergic Synapse Dopaminergic Synapse GABA-ergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Postsynaptic Specialization Membrane
	Molecular Function	Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Thigmotaxis Regulation Of Respiratory Gaseous Exchange By Nervous System Process Cell Adhesion Neuron Cell-cell Adhesion Synapse Assembly Jump Response Positive Regulation Of Cell Population Proliferation Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Cell Surface Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Synaptic Transmission, GABAergic Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Terminal Button Organization Neurotransmitter-gated Ion Channel Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Postsynaptic Specialization Assembly Presynapse Assembly Insulin Metabolic Process Positive Regulation Of Protein Localization To Synapse Positive Regulation Of T-SNARE Clustering Inhibitory Synapse Assembly Regulation Of Presynapse Assembly Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering
Pathways	Neurexins and neuroligins Neurexins and neuroligins
GWAS	Refractive error ( 32231278 ) Uterine fibroids ( 30194396 ) Waist circumference adjusted for body mass index ( 34021172 )
Entrez ID	57555
HPRD ID	07348
Ensembl ID	ENSG00000169992
Uniprot IDs	Q8NFZ4
PDB IDs	5XEQ 8GS4
GO Terms Enriched among Interactors ?	Neuroligin Family Protein Binding Receptor Clustering Protein Localization To Synapse Vocalization Behavior Protein Localization To Cell Junction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Social Behavior Cell-cell Adhesion Neuron Cell-cell Adhesion Neuromuscular Junction Chemical Synaptic Transmission Protein Localization To Membrane Trans-synaptic Signaling Ionotropic Glutamate Receptor Binding Synaptic Signaling Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Establishment Or Maintenance Of Cell Polarity Learning Cell Adhesion Gephyrin Clustering Involved In Postsynaptic Density Assembly Localization Within Membrane NMDA Selective Glutamate Receptor Signaling Pathway Trans-synaptic Protein Complex Postsynaptic Density Protein 95 Clustering Nervous System Development Postsynaptic Membrane Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cell-cell Signaling Vocal Learning Cell Junction Assembly Signaling Learning Or Memory Postsynaptic Membrane Organization Observational Learning Cell Communication Cell Projection Cell Adhesion Molecule Binding Cognition Juxtaparanode Region Of Axon Synapse Assembly Kinase Binding Postsynaptic Density Membrane Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Cellular Response To Potassium Ion Auditory Behavior Mechanosensory Behavior Nervous System Process