ZAP70 and SH2B3 |
zeta-chain (TCR) associated protein kinase 70kDa |
SH2B adaptor protein 3 |
- TCR signaling
- Generation of second messenger molecules
- Translocation of ZAP-70 to Immunological synapse
- Adaptive Immune System
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- Signaling by SCF-KIT
- Regulation of KIT signaling
- Factors involved in megakaryocyte development and platelet production
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ZAP70 and PTPN22 |
zeta-chain (TCR) associated protein kinase 70kDa |
protein tyrosine phosphatase, non-receptor type 22 (lymphoid) |
- TCR signaling
- Generation of second messenger molecules
- Translocation of ZAP-70 to Immunological synapse
- Adaptive Immune System
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MAFK and BACH2 |
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K |
BTB and CNC homology 1, basic leucine zipper transcription factor 2 |
- Factors involved in megakaryocyte development and platelet production
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CREB5 and SPRY2 |
cAMP responsive element binding protein 5 |
sprouty homolog 2 (Drosophila) |
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- Signaling by EGFR
- EGFR downregulation
- Signaling by FGFR in disease
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Spry regulation of FGF signaling
- Signaling by FGFR
- Negative regulation of FGFR signaling
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NFE2L3 and BACH2 |
nuclear factor, erythroid 2-like 3 |
BTB and CNC homology 1, basic leucine zipper transcription factor 2 |
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USP3 and IFIH1 |
ubiquitin specific peptidase 3 |
interferon induced with helicase C domain 1 |
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- TRAF3-dependent IRF activation pathway
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Negative regulators of RIG-I/MDA5 signaling
- TRAF6 mediated IRF7 activation
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- Innate Immune System
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SPRY2 and UBASH3A |
sprouty homolog 2 (Drosophila) |
ubiquitin associated and SH3 domain containing A |
- Signaling by EGFR
- EGFR downregulation
- Signaling by FGFR in disease
- Signaling by EGFR in Cancer
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by EGFRvIII in Cancer
- Spry regulation of FGF signaling
- Signaling by FGFR
- Negative regulation of FGFR signaling
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FOXP3 and IKZF4 |
forkhead box P3 |
IKAROS family zinc finger 4 (Eos) |
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SUFU and GLIS3 |
suppressor of fused homolog (Drosophila) |
GLIS family zinc finger 3 |
- Hedgehog 'off' state
- Hedgehog 'on' state
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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BATF3 and BACH2 |
basic leucine zipper transcription factor, ATF-like 3 |
BTB and CNC homology 1, basic leucine zipper transcription factor 2 |
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PATZ1 and BACH2 |
POZ (BTB) and AT hook containing zinc finger 1 |
BTB and CNC homology 1, basic leucine zipper transcription factor 2 |
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MAFF and BACH2 |
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
BTB and CNC homology 1, basic leucine zipper transcription factor 2 |
- Factors involved in megakaryocyte development and platelet production
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CREB3L1 and SLC30A8 |
cAMP responsive element binding protein 3-like 1 |
solute carrier family 30 (zinc transporter), member 8 |
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- Metal ion SLC transporters
- Peptide hormone metabolism
- Zinc efflux and compartmentalization by the SLC30 family
- Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
- Insulin processing
- Zinc transporters
- SLC-mediated transmembrane transport
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A2M and IL10 |
alpha-2-macroglobulin |
interleukin 10 |
- Lipoprotein metabolism
- Metabolism of lipids and lipoproteins
- Platelet degranulation
- Lipid digestion, mobilization, and transport
- Degradation of the extracellular matrix
- Formation of Fibrin Clot (Clotting Cascade)
- Rho GTPase cycle
- Intrinsic Pathway
- HDL-mediated lipid transport
- Response to elevated platelet cytosolic Ca2+
- Signaling by Rho GTPases
- Platelet activation, signaling and aggregation
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- Becaplermin
- Bacitracin
- Ocriplasmin
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AAMP and PTF1A |
angio-associated, migratory cell protein |
pancreas specific transcription factor, 1a |
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- Regulation of beta-cell development
- Regulation of gene expression in early pancreatic precursor cells
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ABCA1 and LMO7 |
ATP-binding cassette, sub-family A (ABC1), member 1 |
LIM domain 7 |
- Lipoprotein metabolism
- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- HDL-mediated lipid transport
- Metabolism of lipids and lipoproteins
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Lipid digestion, mobilization, and transport
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- Adenosine triphosphate
- Glyburide
- Probucol
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ABL1 and ERBB4 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
erb-b2 receptor tyrosine kinase 4 |
- Role of Abl in Robo-Slit signaling
- CDO in myogenesis
- Axon guidance
- Myogenesis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Factors involved in megakaryocyte development and platelet production
- Signaling by Robo receptor
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
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- Adenosine triphosphate
- Imatinib
- Dasatinib
- N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
- Nilotinib
- Bosutinib
- 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
- MYRISTIC ACID
- 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
- 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
- 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
- Regorafenib
- Ponatinib
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ABL1 and SRC |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
SRC proto-oncogene, non-receptor tyrosine kinase |
- Role of Abl in Robo-Slit signaling
- CDO in myogenesis
- Axon guidance
- Myogenesis
- Fcgamma receptor (FCGR) dependent phagocytosis
- Factors involved in megakaryocyte development and platelet production
- Signaling by Robo receptor
- Regulation of actin dynamics for phagocytic cup formation
- Innate Immune System
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- Adenosine triphosphate
- Imatinib
- Dasatinib
- N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
- Nilotinib
- Bosutinib
- 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
- 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
- MYRISTIC ACID
- 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
- 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
- 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
- Regorafenib
- Ponatinib
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- Dasatinib
- RU84687
- RU79256
- N6-Benzyl Adenosine-5\'-Diphosphate
- RU85493
- RU78262
- Phosphonotyrosine
- Malonic acid
- RU83876
- RU90395
- RU79072
- RU78783
- 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
- PASBN
- RU82129
- PAS219
- DPI59
- RU82197
- Phenylphosphate
- RU78300
- RU79073
- RU82209
- ISO24
- RU85053
- RU78299
- Oxalic Acid
- RU78191
- Citric Acid
- RU81843
- 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE
- Purvalanol A
- Bosutinib
- 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
- 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea
- 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
- N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
- [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
- 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE
- N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE
- (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
- Ponatinib
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ABL2 and ERBB4 |
ABL proto-oncogene 2, non-receptor tyrosine kinase |
erb-b2 receptor tyrosine kinase 4 |
- Role of Abl in Robo-Slit signaling
- Axon guidance
- Signaling by Robo receptor
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- Adenosine triphosphate
- Dasatinib
- 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
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ABO and GRAMD3 |
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) |
GRAM domain containing 3 |
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- Uridine-Diphosphate-N-Acetylgalactosamine
- Uridine-5\'-Diphosphate
- Uridine Diphosphate Galactose
- 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,5-Diol
- 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
- H TYPE II TRISACCHARIDE
- H TYPE I TRISACCHARIDE
- GALACTOSE GREASE
- BETA-METHYLLACTOSIDE
- octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranoside
- 4-AMINO-2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL
- 4-AMINO-2-OCTYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,5-DIOL
- octyl 3-deoxy-2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-xylo-hexopyranoside
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