CASP8AP2 and MX1

Number of citations of the paper that reports this interaction (PubMedID 25447205)
0

Data Source:
BioGRID (two hybrid)

		CASP8AP2	MX1
Description		caspase 8 associated protein 2	MX dynamin like GTPase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Negative Regulation Of DNA-templated Transcription Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways		SUMOylation of transcription cofactors	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Asthma ( 31959851) Estimated glomerular filtration rate in non-diabetics ( 31451708) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602)
Interacting Genes		21 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL KLHL20 MX1 NAA10 NR3C2 PML RAD51 SP100 SREBF2 TCL1A TRAF2 TRIM21 UBE2I	42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623
Entrez ID		9994	4599
HPRD ID		06048	00919
Ensembl ID		ENSG00000118412	ENSG00000157601
Uniprot IDs		Q9UKL3	H9KVC7 P20591
PDB IDs		2LR8 6ANO 6AOZ 6AP0	3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?		CD95 Death-inducing Signaling Complex Death Effector Domain Binding Ripoptosome Positive Regulation Of Signal Transduction Death-inducing Signaling Complex Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Identical Protein Binding PML Body Cytosol Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Execution Phase Of Apoptosis Response To Cytokine Cytoplasm Response To Peptide Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Nucleus TRAIL-activated Apoptotic Signaling Pathway Apoptotic Process Signal Transduction Cell Death Response To Stress Programmed Cell Death Regulation Of Apoptotic Signaling Pathway N-terminal Protein Amino Acid Acetylation Response To Type I Interferon Cellular Response To Mechanical Stimulus Positive Regulation Of Biosynthetic Process Negative Regulation Of Viral Process Cell Body Motor Neuron Apoptotic Process Negative Regulation Of RNA Metabolic Process	Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing
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