CDC26

Description		cell division cycle 26
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: CTLA4
Interacting Genes		3 interacting genes: ANAPC2 CDC27 LATS1
Entrez ID		246184
HPRD ID		13012
Ensembl ID		ENSG00000176386
Uniprot IDs		Q8NHZ8
PDB IDs		3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Metaphase/anaphase Transition Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Branched Polyubiquitination Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Reproductive Process Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Cell Cycle Spindle Regulation Of Chromosome Organization Protein Complex Involved In Cell Adhesion Regulation Of Organelle Organization Negative Regulation Of Regulatory T Cell Differentiation Protein Polyubiquitination Regulation Of Synapse Organization Positive Regulation Of Synapse Maturation Regulation Of Developmental Growth Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Plasticity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Cullin-RING Ubiquitin Ligase Complex Regulation Of Postsynaptic Density Assembly Negative Regulation Of B Cell Proliferation Proteasomal Protein Catabolic Process Mammary Gland Epithelial Cell Differentiation Regulation Of Postsynaptic Specialization Assembly Positive Regulation Of Hippo Signaling Regulation Of Excitatory Synapse Assembly Regulation Of Mitotic Cell Cycle NLRP3 Inflammasome Complex Assembly Clathrin-coated Endocytic Vesicle Positive Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Programmed Cell Death Hippo Signaling Regulation Of Synapse Maturation Protein Catabolic Process Protein Ubiquitination
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