GOLGA5 and OCRL

Number of citations of the paper that reports this interaction (PubMedID 9915833)
0

Data Source:
HPRD (two hybrid)

		GOLGA5	OCRL
Description		golgin A5	OCRL inositol polyphosphate-5-phosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle Golgi Cisterna	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Cilium Microtubule Cytoskeleton Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	Small GTPase Binding Protein Homodimerization Activity	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Hydrolase Activity Phosphatase Activity Small GTPase Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Bisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity
	Biological Process	Retrograde Transport, Vesicle Recycling Within Golgi Golgi Organization Golgi Vesicle Transport	In Utero Embryonic Development Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Cell Projection Organization Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Cilium Assembly Membrane Organization
Pathways		Intra-Golgi traffic	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases			Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS		Body mass index ( 26426971)
Interacting Genes		4 interacting genes: CUX1 ITSN1 OCRL RAB1A	13 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1 TFAP2A
Entrez ID		9950	4952
HPRD ID		06079	02395
Ensembl ID		ENSG00000066455	ENSG00000122126
Uniprot IDs		Q8TBA6	A0A2X0TVZ9 Q01968 Q504W7
PDB IDs			2KIE 2QV2 3QBT 3QIS 4CMN
Enriched GO Terms of Interacting Partners?		Collagen Type XV Trimer Golgi Apparatus Clathrin-coated Pit Phosphatidylinositol Bisphosphate Phosphatase Activity Clathrin-dependent Synaptic Vesicle Endocytosis Cortical Microtubule Plus-end Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Endosome Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Growth Hormone Secretion Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Caveolin-mediated Endocytosis Molecular Adaptor Activity Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Cilium Assembly Endomembrane System Virion Assembly Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Microtubule Nucleation Golgi Vesicle Transport Astral Microtubule Organization	GTPase Activity Vesicle-mediated Transport GTP Binding G Protein Activity Phagocytic Vesicle Endocytosis Intracellular Protein Transport Import Into Cell Receptor Internalization Trans-Golgi Network Myosin V Binding GDP Binding Cellular Localization Endosome Intracellular Transport Melanosome Intracellular Protein Localization Trans-Golgi Network Membrane Endosomal Transport Endomembrane System Cytoplasmic Vesicle Golgi Vesicle Transport Golgi Organization Extracellular Exosome Golgi Membrane Establishment Of Localization In Cell Protein Transport Receptor-mediated Endocytosis Hydrolase Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Early Endosome Membrane Nucleotide Binding Protein Kinase Binding Establishment Of Protein Localization Thioesterase Binding Plasma Membrane Bounded Cell Projection Organization Golgi Apparatus Phagocytic Vesicle Membrane Phagosome Maturation Organelle Transport Along Microtubule Localization Within Membrane Secretory Granule Membrane Retrograde Transport, Endosome To Golgi Recycling Endosome Membrane Trans-Golgi Network Transport Vesicle Early Endosome To Golgi Transport Protein Localization To Membrane Anatomical Structure Arrangement
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