RBM8A and UPF3A

Number of citations: 0 (PubMedID 11546873)
Data Source: HPRD (in vivo)

		RBM8A	UPF3A
Name		RNA binding motif protein 8A	UPF3A regulator of nonsense mediated mRNA decay
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Exon-exon Junction Complex Neuron Projection
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay In Utero Embryonic Development Spermatogenesis Positive Regulation Of Translation MRNA Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GWAS		No GWAS studies recorded	Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Nodular sclerosis Hodgkin lymphoma ( 29196614 ) Pulse pressure ( 30578418 )
Novel Interactors		1 novel interactors: PDE4DIP	1 novel interactors: ERBB2
Interacting Genes		17 interacting genes: APP CDC42 DPH1 EIF4A3 FBXO25 IKBKG IPO13 KAT2B MAGOH MAGOHB MCM7 SF3B2 SRPK2 TCF12 TOE1 UPF3A UPF3B	9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1
Entrez ID		9939	65110
HPRD ID		05609	09274
Ensembl ID		ENSG00000265241	ENSG00000169062
Uniprot IDs		A0A023T787 Q9Y5S9	B3KUE7 Q9H1J1
PDB IDs		1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 5XJC 5YZG 6ICZ 6QDV 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD	2L08 7QG6
GO Terms Enriched among Interactors		Exon-exon Junction Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Transport MRNA Catabolic Process Regulation Of MRNA Processing RNA Transport Nucleus Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing RNA Catabolic Process MRNA Metabolic Process Nucleobase-containing Compound Transport Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14 Nuclear Speck Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nucleoplasm Positive Regulation Of Gene Expression Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process RNA Splicing Nucleolus Spliceosomal Complex RNA Metabolic Process MRNA Export From Nucleus MRNA Splicing, Via Spliceosome Regulation Of Translation RNA Splicing, Via Transesterification Reactions MRNA Processing U2-type Catalytic Step 1 Spliceosome Nucleic Acid Metabolic Process RNA Export From Nucleus Negative Regulation Of Gene Expression Positive Regulation Of Neuron Differentiation Nuclear Transport Nucleocytoplasmic Transport RNA Processing Positive Regulation Of Glycolytic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cytoplasm Post-transcriptional Regulation Of Gene Expression Nuclear Export Positive Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle Positive Regulation Of MRNA Splicing, Via Spliceosome Neuronal Cell Body	MRNA Export From Nucleus RNA Export From Nucleus Nuclear Export MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport Exon-exon Junction Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Translation Cellular Localization Post-transcriptional Regulation Of Gene Expression Intracellular Transport Transcription Export Complex Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Establishment Of Localization In Cell Telomeric DNA Binding RNA Catabolic Process Response To Cytokine Response To Peptide Negative Regulation Of Gene Expression Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Peptidyl-serine Phosphorylation MRNA Metabolic Process Negative Regulation Of Protein Localization To Nucleus MRNA Binding Cellular Response To Amyloid-beta Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Microtubule Anchoring At Centrosome Glial Cell Development Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Nucleobase-containing Compound Catabolic Process RNA Binding Acetylcholine Receptor Activator Activity Response To Interleukin-1 Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Phosphorylation