RBM8A and DPH1

Number of citations: 0 (PubMedID 11013075)
Data Source: HPRD (two hybrid)

		RBM8A	DPH1
Name		RNA binding motif protein 8A	diphthamide biosynthesis 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Protein Binding Transferase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation RNA Splicing Regulation Of MRNA Processing MRNA Transport Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Protein Histidyl Modification To Diphthamide Fibroblast Proliferation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Synthesis of diphthamide-EEF2
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Diisocyanate-induced asthma ( 25918132 ) Hepatocyte growth factor levels ( 25998175 ) Itch intensity from mosquito bite ( 28199695 )
Novel Interactors		1 novel interactors: PDE4DIP	None recorded
Interacting Genes		17 interacting genes: APP CDC42 DPH1 EIF4A3 FBXO25 IKBKG IPO13 KAT2B MAGOH MAGOHB MCM7 SF3B2 SRPK2 TCF12 TOE1 UPF3A UPF3B	4 interacting genes: HSPA5 RBM8A TFCP2 UBC
Entrez ID		9939	1801
HPRD ID		05609	04634
Ensembl ID		ENSG00000265241	ENSG00000108963
Uniprot IDs		A0A023T787 Q9Y5S9	Q9BZG8
PDB IDs		1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 5XJC 5YZG 6ICZ 6QDV 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD	Not available
GO Terms Enriched among Interactors		Exon-exon Junction Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Transport MRNA Catabolic Process Regulation Of MRNA Processing RNA Transport Nucleus Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing RNA Catabolic Process MRNA Metabolic Process Nucleobase-containing Compound Transport Catalytic Step 2 Spliceosome Exon-exon Junction Subcomplex Mago-y14 Nuclear Speck Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nucleoplasm Positive Regulation Of Gene Expression Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process RNA Splicing Nucleolus Spliceosomal Complex RNA Metabolic Process MRNA Export From Nucleus MRNA Splicing, Via Spliceosome Regulation Of Translation RNA Splicing, Via Transesterification Reactions MRNA Processing U2-type Catalytic Step 1 Spliceosome Nucleic Acid Metabolic Process RNA Export From Nucleus Negative Regulation Of Gene Expression Positive Regulation Of Neuron Differentiation Nuclear Transport Nucleocytoplasmic Transport RNA Processing Positive Regulation Of Glycolytic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cytoplasm Post-transcriptional Regulation Of Gene Expression Nuclear Export Positive Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle Positive Regulation Of MRNA Splicing, Via Spliceosome Neuronal Cell Body	Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum Macromolecule Catabolic Process PERK-mediated Unfolded Protein Response ER Overload Response Post-translational Protein Targeting To Membrane, Translocation Cerebellum Structural Organization Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Cerebellar Purkinje Cell Layer Development Ubiquitin Protein Ligase Binding Protein Folding In Endoplasmic Reticulum Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of IRE1-mediated Unfolded Protein Response U2-type Catalytic Step 1 Spliceosome Exon-exon Junction Subcomplex Mago-y14 Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Protein Tag Activity Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Misfolded Protein Binding Anatomical Structure Arrangement