SH3YL1 and ERRFI1

Number of citations of the paper that reports this interaction (PubMedID 20351267)
44

Data Source:
BioGRID (two hybrid)

		SH3YL1	ERRFI1
Description		SH3 and SYLF domain containing 1	ERBB receptor feedback inhibitor 1
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GO Annotations	Cellular Component	Ruffle Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Phosphatase Binding Phosphatidylinositol Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Small GTPase Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Regulation Of Ruffle Assembly	Skeletal System Development Liver Development Tissue Homeostasis Glucose Metabolic Process Lipid Metabolic Process Bile Acid Biosynthetic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Embryo Implantation Cholesterol Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cell Migration Negative Regulation Of Protein Autophosphorylation Response To Estradiol Response To Progesterone Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Uterine Epithelium Development Chondrocyte Proliferation Limb Joint Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cholesterol Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Response To Steroid Hormone Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Cartilage Development Uterus Development Lung Vasculature Development Lung Epithelium Development Epithelium Development Fat Pad Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To 1-oleoyl-sn-glycerol 3-phosphate
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Large artery stroke ( 28265093) Mitochondrial DNA levels ( 25240745) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Crohn's disease ( 28067908) Hair shape ( 29220522) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		11 interacting genes: AR ERRFI1 GFAP HELZ KHDRBS1 PRB3 SH3D19 SYNJ1 VIM VPS37B ZBTB7B	58 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 GAS1 GNPDA2 GTF2H2 HYDIN IL2RG MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SKIC8 SLC61A1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WEE1 YWHAB ZPBP
Entrez ID		26751	54206
HPRD ID		15336	09218
Ensembl ID		ENSG00000035115	ENSG00000116285
Uniprot IDs		Q96HL8	B3KTV8 I6S2Y9 Q9UJM3
PDB IDs		2D8H	2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV
Enriched GO Terms of Interacting Partners?		Bergmann Glial Cell Differentiation Astrocyte Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Gene Expression Cellular Response To Steroid Hormone Stimulus Nuclear Receptor-mediated Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Schwann Cell Proliferation Astrocyte Differentiation Kinase Binding Intermediate Filament Organization Schwann Cell Proliferation Glial Cell Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Synaptic Vesicle Uncoating Positive Regulation Of Endosome Organization Grb2-Sos Complex Negative Regulation Of NK T Cell Activation Negative Regulation Of NK T Cell Proliferation Positive Regulation Of SREBP Signaling Pathway Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Positive Regulation Of Viral Budding Via Host ESCRT Complex Male Genitalia Morphogenesis POU Domain Binding Glial Cell Differentiation Phosphatidylinositol Phosphate 4-phosphatase Activity SH3 Domain Binding NK T Cell Differentiation Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Cellular Response To Lipid Negative Regulation Of Neuron Projection Development	Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Enzyme Binding ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Activity Protein Autophosphorylation Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Activity Protein Phosphorylation Phosphoserine Residue Binding Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Phosphorylation Protein Kinase Activity ERBB2-EGFR Signaling Pathway Cellular Response To Growth Factor Stimulus Ruffle Membrane Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process Animal Organ Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Response To Estradiol Endothelin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Receptor Complex Response To Epidermal Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Progesterone Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cis-Golgi Network Membrane Cell Cycle G2/M Phase Transition DNA Repair Complex
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