PIWIL4

Description		piwi like RNA-mediated gene silencing 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion P Granule PiP-body
	Molecular Function	Nucleic Acid Binding RNA Binding RNA Endonuclease Activity PiRNA Binding
	Biological Process	Regulation Of Translation Spermatogenesis Epithelial Structure Maintenance Cell Differentiation Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Meiotic Cell Cycle Secondary PiRNA Processing Transposable Element Silencing By Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated DNA Methylation
Pathways		PIWI-interacting RNA (piRNA) biogenesis Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptoms (maternal expressed emotions interaction) ( 18846501) Chromium levels ( 26025379) Colorectal cancer ( 29228715) Mood disorder and prion disease ( 25897833) Mood disorder in prion disease ( 25897833) Small cell lung carcinoma ( 28604730)
Interacting Genes		3 interacting genes: DICER1 RNF10 VHL
Entrez ID		143689
HPRD ID		11435
Ensembl ID		ENSG00000134627
Uniprot IDs		A0A140VKG8 Q7Z3Z4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Negative Regulation Of Cell Population Proliferation Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Regulatory RNA Binding Negative Regulation Of Nervous System Development Macromolecule Catabolic Process Peripheral Nervous System Myelin Formation Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Development Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Cell Population Proliferation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Transcription Elongation Factor Activity Catabolic Process Regulation Of Neurogenesis RISC-loading Complex SiRNA Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding RISC Complex Assembly Regulation Of Nervous System Development SiRNA Binding TRNA Decay Apoptotic DNA Fragmentation Proteasomal Protein Catabolic Process Pre-miRNA Processing Myelin Assembly Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Regulation Of System Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Response To Hypoxia Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination
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