SEC16A and SEC23A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		SEC16A	SEC23A
Description		SEC16 homolog A, endoplasmic reticulum export factor	SEC23 homolog A, COPII component
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Organelle Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of COPII Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Endoplasmic Reticulum Organization Golgi Organization Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Substantia Nigra Development Protein Exit From Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Protein Stabilization Localization Within Membrane Protein Localization To Endoplasmic Reticulum Exit Site Protein Localization To Plasma Membrane	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding
Pathways		COPII-mediated vesicle transport	Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eosinophil count ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Inflammatory bowel disease ( 28067908) Monocyte percentage of white cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Squamous cell carcinoma ( 31174203) Triglyceride levels ( 32154731) Ulcerative colitis ( 21297633 28067908)	Metabolite levels ( 23823483) Vitamin D levels ( 29343764)
Interacting Genes		2 interacting genes: MIA3 SEC23A	33 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23IP SEC24B SEC24C SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11
Entrez ID		9919	10484
HPRD ID		11075	06714
Ensembl ID		ENSG00000148396	ENSG00000100934
Uniprot IDs		A0A8I5KPG1 F1T0I1 O15027	Q15436
PDB IDs			2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO 8HR0
Enriched GO Terms of Interacting Partners?		COPII-coated Vesicle Cargo Loading Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport COPII-coated Vesicle Budding Protein Localization To Endoplasmic Reticulum Exit Site COPII Vesicle Coat Lipoprotein Transport Negative Regulation Of Lymphocyte Migration Protein Localization To Endoplasmic Reticulum Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Vesicle Budding From Membrane Endoplasmic Reticulum Membrane Vesicle-mediated Transport COPII-coated ER To Golgi Transport Vesicle Intracellular Transport Protein Transport Cellular Response To Lipoprotein Particle Stimulus Cargo Receptor Activity Blood Vessel Endothelial Cell Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Mononuclear Cell Migration Establishment Of Protein Localization Cellular Localization ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum Establishment Of Localization In Cell Endoplasmic Reticulum Organization Regulation Of Lymphocyte Migration Negative Regulation Of Leukocyte Migration Wound Healing Endothelial Cell Migration Intracellular Protein Localization Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Negative Regulation Of Leukocyte Cell-cell Adhesion	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Exit Site Golgi Vesicle Transport Protein Localization To Endoplasmic Reticulum Exit Site Vesicle Cargo Loading Protein Localization To Endoplasmic Reticulum ER To Golgi Transport Vesicle Membrane COPII-coated Vesicle Cargo Loading Vesicle-mediated Transport Membrane Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Intracellular Transport Regulation Of Plasma Membrane Organization COPII Vesicle Coat Lipoprotein Transport Establishment Of Protein Localization Positive Regulation Of Mitochondrial Fission Mitochondrial Calcium Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Protein Transport
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