NCAPD2 and SMC2

Number of citations of the paper that reports this interaction (PMID 10958694)
34

Data Source:
HPRD (in vivo)

		NCAPD2	SMC2
Gene Name		non-SMC condensin I complex, subunit D2	structural maintenance of chromosomes 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Condensin Complex Condensin Core Heterodimer Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Pronucleus	Nuclear Chromosome Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Histone Binding	Protein Binding ATP Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Cell Division	Mitotic Cell Cycle Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization
Pathways		Mitotic Prometaphase Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes	Mitotic Prometaphase Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS			Orofacial clefts (interaction) ( 21618603)
Protein-Protein Interactions		5 interactors: CDK1 CSNK2A1 NCAPH SMC2 SMC4	8 interactors: ABCC5 DISC1 DNMT3B GULP1 LIG4 NCAPD2 SMC4 TRAF3IP1
Entrez ID		9918	10592
HPRD ID		06472	09277
Ensembl ID		ENSG00000010292	ENSG00000136824
Uniprot IDs		B3KMS0 B3KY03 F5GZJ1 Q15021	A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Condensation Mitotic Chromosome Condensation DNA Packaging Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Conformation Change Meiotic Chromosome Condensation Mitotic Nuclear Division Cell Cycle Process Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Division Cell Cycle Chromosome Segregation Kinetochore Organization Chromosome Organization DNA Metabolic Process Meiotic Chromosome Segregation Pronuclear Fusion Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Meiotic Nuclear Division Nitrogen Compound Metabolic Process Meiotic Cell Cycle Reproduction Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Growth Cell Cycle Checkpoint Regulation Of Schwann Cell Differentiation Organelle Organization Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Ventricular Cardiac Muscle Cell Development Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis	Mitotic Chromosome Condensation Chromosome Condensation Organelle Organization Chromosome Organization DNA Metabolic Process Positive Regulation Of Neurogenesis Mitotic Sister Chromatid Segregation Cell Division DNA Ligation Involved In DNA Recombination Sister Chromatid Segregation Positive Regulation Of Cell Development S-adenosylmethioninamine Metabolic Process Response To Ionizing Radiation Regulation Of Neurogenesis Meiotic Chromosome Condensation DNA Methylation On Cytosine Within A CG Sequence DNA Packaging C-5 Methylation Of Cytosine Lagging Strand Elongation Pro-B Cell Differentiation S-adenosylhomocysteine Metabolic Process Regulation Of Cell Development Positive Regulation Of Cell Differentiation Chromosome Segregation Methylation-dependent Chromatin Silencing Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Hyaluronan Biosynthetic Process DNA Ligation Involved In DNA Repair DNA Conformation Change Lymphoid Progenitor Cell Differentiation Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Nervous System Development Phagocytosis, Engulfment Mitotic Nuclear Division Negative Regulation Of Interferon-beta Production DNA Ligation Positive Regulation Of Histone H3-K4 Methylation Nucleotide-excision Repair, DNA Gap Filling Mitochondrial Calcium Ion Homeostasis Cellular Response To Lithium Ion Membrane Invagination Protein Complex Localization Negative Regulation Of Histone Methylation Regulation Of Synapse Maturation Post-anal Tail Morphogenesis
Tagcloud ?		aberration birc5 bub1 candidates cysts datasets defining driver dysregulated epcam epithelium estrous fallopian hormones inclusion list nuak2 ovarian ovulation ovulations ovulatory prioritised proestrus publically represented segregation serous silico tube	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase
Tagcloud (Difference) ?		aberration birc5 bub1 candidates cysts datasets defining driver dysregulated epcam epithelium estrous fallopian hormones inclusion list nuak2 ovarian ovulation ovulations ovulatory prioritised proestrus publically represented segregation serous silico tube	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase
Tagcloud (Intersection) ?