NCAPD2 and SMC2

Number of citations of the paper that reports this interaction (PubMedID 10958694)
26

Data Source:
HPRD (in vivo)

		NCAPD2	SMC2
Description		non-SMC condensin I complex subunit D2	structural maintenance of chromosomes 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome, Centromeric Region Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane Centriolar Satellite Ciliary Basal Body	Nuclear Chromosome Chromatin Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Histone Binding	Nucleotide Binding Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Cell Division Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation	Nuclear Division Mitotic Chromosome Condensation Meiotic Chromosome Condensation Chromosome Condensation Meiotic Chromosome Segregation Chromosome Organization Cell Division Kinetochore Organization Positive Regulation Of Chromosome Segregation Nuclear Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways		Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203 33549134) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)
Interacting Genes		7 interacting genes: CDC42 CDK1 CNN1 CSNK2A1 SMC2 SMC4 SUMO2	11 interacting genes: ABCC5 CDC42 CEBPA DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 TRAF3IP1
Entrez ID		9918	10592
HPRD ID		06472	09277
Ensembl ID		ENSG00000010292	ENSG00000136824
Uniprot IDs		B3KMS0 B3KY03 Q15021	A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1
PDB IDs			4U4P
Enriched GO Terms of Interacting Partners?		Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Chromosome Condensation Positive Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Positive Regulation Of Chromosome Organization Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Mitotic Chromosome Condensation Kinetochore Organization Regulation Of Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Organelle Organization Protein Localization To Site Of Double-strand Break Positive Regulation Of Chromosome Separation Regulation Of Chromosome Organization Positive Regulation Of Growth Organelle Organization Condensed Nuclear Chromosome Nuclear Chromosome Segregation Chromosome Organization Involved In Meiotic Cell Cycle Pronuclear Fusion Chromosome Organization Nucleotide Binding Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cell Division DNA Damage Checkpoint Signaling GBD Domain Binding Storage Vacuole Nuclear Division Positive Regulation Of Cellular Component Organization Protein Localization To Chromosome Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Golgi Organization Regulation Of Organelle Organization Chromatin Binding Cyclin-dependent Protein Kinase Activity Supramolecular Fiber Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body	Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Organelle Organization Dendritic Spine Morphogenesis Response To Lithium Ion Cellular Response To Lithium Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Organization Mitotic Chromosome Condensation Regulation Of Chromosome Condensation Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Embryonic Heart Tube Development Phagocytosis, Engulfment Positive Regulation Of Chromosome Segregation Dendritic Spine Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chromosome Separation Condensed Chromosome Positive Regulation Of Organelle Organization Response To Electrical Stimulus Chromosome Condensation Positive Regulation Of Proteolysis Neuron Projection Organization Postsynapse Organization System Development Regulation Of Cell-substrate Adhesion Ciliary Base Macrophage Differentiation Membrane Invagination Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency Regulation Of Chromosome Organization Negative Regulation Of Synaptic Vesicle Clustering Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Process Mononuclear Cell Differentiation GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Cycle
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