AREL1 and NPC2

		AREL1	NPC2
Description		apoptosis resistant E3 ubiquitin protein ligase 1	NPC intracellular cholesterol transporter 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein K11-linked Ubiquitination Protein K33-linked Ubiquitination	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Response To Virus Gene Expression Cholesterol Storage Phospholipid Transport Sterol Transport Sterol Metabolic Process Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Mood instability ( 29187730)	Intraocular pressure ( 31959993) Refractive error ( 32231278) Soluble receptor for advanced glycation end-product levels ( 26915486)
Interacting Genes		10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3	9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4
Entrez ID		9870	10577
HPRD ID		13794	03008
Ensembl ID		ENSG00000119682	ENSG00000119655
Uniprot IDs		A0A7P0T811 O15033	A0A024R6C0 G3V3E8 P61916
PDB IDs		6JX5 6LOH	5KWY 6W5V
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification By Small Protein Conjugation Regulation Of Protein Targeting To Mitochondrion Post-translational Protein Modification Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process CD40 Receptor Complex Macromolecule Catabolic Process Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Localization Programmed Cell Death Negative Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Cytosol Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Apoptotic Process Protein Modification Process Positive Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Pentacyclic Triterpenoid Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Helper T Cell Diapedesis Mitochondrial Intermembrane Space Negative Regulation Of Type 2 Mitophagy Limb Epidermis Development	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Response To Ionizing Radiation Cellular Response To Ionizing Radiation BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Cellular Response To Radiation Ubiquitin-modified Histone Reader Activity Response To Radiation DNA Strand Resection Involved In Replication Fork Processing DNA Recombination Response To Stress Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Macromolecule Metabolic Process Protein K6-linked Ubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Activity Condensed Chromosome Homologous Recombination Regulation Of Protein Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Integrated Proviral Latency Adenosine Receptor Binding Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Adipose Tissue Development Mitotic G2/M Transition Checkpoint Post-translational Protein Modification DNA Repair Establishment Of Viral Latency Protein K33-linked Ubiquitination Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate
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