ZEB2 and COL16A1

Data Source: HiPPIP (Novel)

		ZEB2	COL16A1
Name		zinc finger E-box binding homeobox 2	collagen type XVI alpha 1 chain
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Plasma Membrane	Extracellular Region Collagen Trimer Collagen Type XVI Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding	Integrin Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Somitogenesis Neural Tube Closure Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Negative Regulation Of Fibroblast Migration Corpus Callosum Morphogenesis Hippocampus Development Cell Proliferation In Forebrain Corticospinal Tract Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Myofibroblast Differentiation Stress Fiber Assembly Endothelial Cell Migration Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Astrocyte Activation Embryonic Morphogenesis Collateral Sprouting Positive Regulation Of Axonogenesis Mammillary Axonal Complex Development Pyroptotic Inflammatory Response Fibroblast Activation Positive Regulation Of Canonical Wnt Signaling Pathway Response To Oxygen-glucose Deprivation Melanocyte Migration Positive Regulation Of Lens Fiber Cell Differentiation Regulation Of Melanosome Organization Positive Regulation Of Myofibroblast Contraction Regulation Of Myofibroblast Cell Apoptotic Process Regulation Of Blood-brain Barrier Permeability	Cell Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Integrin Activation Cell Adhesion Mediated By Integrin Positive Regulation Of Focal Adhesion Assembly Cellular Response To Amino Acid Stimulus
Pathways		Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription Positive Regulation of CDH1 Gene Transcription Formation of the anterior neural plate Formation of the posterior neural plate	Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Diseases		Mowat-Wilson syndrome	None
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Age-related nuclear cataracts ( 33311586 ) Childhood absence epilepsy ( 30531953 ) Chin dimples ( 27182965 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Corneal astigmatism ( 30306274 ) Coronary artery disease ( 29212778 32469254 26343387 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Diastolic blood pressure ( 30224653 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General risk tolerance (MTAG) ( 30643258 ) Generalized epilepsy ( 22949513 ) Hand grip strength ( 29691431 ) High myopia ( 31816047 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 ) Mean corpuscular volume ( 29403010 ) Medication use (diuretics) ( 31015401 ) Myocardial infarction ( 33532862 26343387 ) Obesity-related traits ( 23251661 ) Photic sneeze reflex ( 30899065 27182965 ) Red blood cell count ( 29403010 ) Refractive error ( 32231278 ) Renal cell carcinoma ( 25826619 23184150 ) Retinal detachment or retinal break ( 31816047 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Schizophrenia ( 29483656 23974872 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Triglyceride levels ( 32203549 )	Asthma ( 31959851 32296059 ) Body mass index ( 25673413 26426971 ) General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Severe aortic features in Marfan syndrome ( 30087447 )
Interacting Genes		16 interacting genes: APP CBX4 COPS6 CTBP1 CTBP2 DDB1 DGKG FBXO45 MTA1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I USP16	None recorded
Entrez ID		9839	1307
HPRD ID		05780	00381
Ensembl ID		ENSG00000169554	ENSG00000084636
Uniprot IDs		O60315	Q07092
PDB IDs		2DA7	Not available
GO Terms Enriched among Interactors		SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway DEAD/H-box RNA Helicase Binding Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Co-SMAD Binding Primary MiRNA Processing Embryonic Pattern Specification Response To Growth Factor Regulation Of Transcription By RNA Polymerase II Kidney Epithelium Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Homomeric SMAD Protein Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Fate Commitment Paraxial Mesoderm Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex MiRNA Processing Chromatin Binding Regulation Of DNA-templated Transcription Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Osteoblast Differentiation Regulation Of Macromolecule Metabolic Process Anti-Mullerian Hormone Receptor Signaling Pathway Mesoderm Morphogenesis Transcription Coregulator Binding Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Biosynthetic Process Pericardium Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding Regulation Of RNA Metabolic Process	Regulation Of Melanosome Organization Regulation Of Myofibroblast Contraction Mammillary Axonal Complex Development Regulation Of Myofibroblast Cell Apoptotic Process Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Myofibroblast Contraction Phosphatase Regulator Activity Regulation Of Melanocyte Differentiation Corticospinal Tract Morphogenesis Melanocyte Migration Myofibroblast Differentiation Corpus Callosum Morphogenesis Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Melanocyte Differentiation Fibroblast Activation Positive Regulation Of Developmental Pigmentation Regulation Of Lens Fiber Cell Differentiation Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Melanin Biosynthetic Process Response To Oxygen-glucose Deprivation Regulation Of Melanin Biosynthetic Process Regulation Of Developmental Pigmentation Cell Proliferation In Forebrain Negative Regulation Of Fibroblast Migration Developmental Pigmentation Collateral Sprouting Astrocyte Activation Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Central Nervous System Projection Neuron Axonogenesis R-SMAD Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Axonogenesis Epithelial Cell Migration Endothelial Cell Proliferation Regulation Of Fibroblast Migration Pyroptotic Inflammatory Response Somitogenesis Regulation Of Vascular Permeability Pigmentation Segmentation Neural Crest Cell Migration Mesenchymal Cell Migration Actin Filament Bundle Assembly Positive Regulation Of Epithelial Cell Differentiation Actin Filament Bundle Organization Hippocampus Development Positive Regulation Of Axonogenesis Endothelial Cell Migration Neural Tube Closure