ZEB2 and QTMAN

Data Source: HiPPIP (Novel)

		ZEB2	QTMAN
Name		zinc finger E-box binding homeobox 2	queuosine-tRNA mannosyltransferase
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Plasma Membrane	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Phosphatase Regulator Activity Metal Ion Binding R-SMAD Binding	TRNA-queuosine(34) Beta-mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Somitogenesis Neural Tube Closure Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Negative Regulation Of Fibroblast Migration Corpus Callosum Morphogenesis Hippocampus Development Cell Proliferation In Forebrain Corticospinal Tract Morphogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Myofibroblast Differentiation Stress Fiber Assembly Endothelial Cell Migration Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Melanin Biosynthetic Process Developmental Pigmentation Astrocyte Activation Embryonic Morphogenesis Collateral Sprouting Positive Regulation Of Axonogenesis Mammillary Axonal Complex Development Pyroptotic Inflammatory Response Fibroblast Activation Positive Regulation Of Canonical Wnt Signaling Pathway Response To Oxygen-glucose Deprivation Melanocyte Migration Positive Regulation Of Lens Fiber Cell Differentiation Regulation Of Melanosome Organization Positive Regulation Of Myofibroblast Contraction Regulation Of Myofibroblast Cell Apoptotic Process Regulation Of Blood-brain Barrier Permeability	TRNA Modification Regulation Of Translation
Pathways		Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription Positive Regulation of CDH1 Gene Transcription Formation of the anterior neural plate Formation of the posterior neural plate	None
Diseases		Mowat-Wilson syndrome	None
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Age-related nuclear cataracts ( 33311586 ) Childhood absence epilepsy ( 30531953 ) Chin dimples ( 27182965 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Corneal astigmatism ( 30306274 ) Coronary artery disease ( 29212778 32469254 26343387 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Diastolic blood pressure ( 30224653 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) General risk tolerance (MTAG) ( 30643258 ) Generalized epilepsy ( 22949513 ) Hand grip strength ( 29691431 ) High myopia ( 31816047 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 29403010 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 ) Mean corpuscular volume ( 29403010 ) Medication use (diuretics) ( 31015401 ) Myocardial infarction ( 33532862 26343387 ) Obesity-related traits ( 23251661 ) Photic sneeze reflex ( 30899065 27182965 ) Red blood cell count ( 29403010 ) Refractive error ( 32231278 ) Renal cell carcinoma ( 25826619 23184150 ) Retinal detachment or retinal break ( 31816047 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Schizophrenia ( 29483656 23974872 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Triglyceride levels ( 32203549 )	No GWAS studies recorded
Interacting Genes		16 interacting genes: APP CBX4 COPS6 CTBP1 CTBP2 DDB1 DGKG FBXO45 MTA1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 UBE2I USP16	1 interacting genes: APP
Entrez ID		9839	79712
HPRD ID		05780	13615
Ensembl ID		ENSG00000169554	ENSG00000121964
Uniprot IDs		O60315	B8ZZ45 Q4AE62
PDB IDs		2DA7	Not available
GO Terms Enriched among Interactors		SMAD Protein Complex Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway DEAD/H-box RNA Helicase Binding Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Co-SMAD Binding Primary MiRNA Processing Embryonic Pattern Specification Response To Growth Factor Regulation Of Transcription By RNA Polymerase II Kidney Epithelium Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Homomeric SMAD Protein Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Fate Commitment Paraxial Mesoderm Morphogenesis Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex MiRNA Processing Chromatin Binding Regulation Of DNA-templated Transcription Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Osteoblast Differentiation Regulation Of Macromolecule Metabolic Process Anti-Mullerian Hormone Receptor Signaling Pathway Mesoderm Morphogenesis Transcription Coregulator Binding Regulation Of Gene Expression Nucleoplasm Positive Regulation Of Biosynthetic Process Pericardium Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding Regulation Of RNA Metabolic Process	Collateral Sprouting Astrocyte Activation Amyloid-beta Complex Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Developmental Cell Growth Developmental Growth Involved In Morphogenesis Axonogenesis Mammillary Axonal Complex Development Positive Regulation Of Myofibroblast Contraction Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Canonical Wnt Signaling Pathway Cell Projection Morphogenesis Regulation Of Wnt Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Neuron Projection Morphogenesis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Melanosome Organization Regulation Of Myofibroblast Contraction Regulation Of Myofibroblast Cell Apoptotic Process Positive Regulation Of Lens Fiber Cell Differentiation Melanocyte Migration Developmental Growth Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Melanocyte Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Melanocyte Differentiation Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity