SPOCK2 and PLXNB3

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		SPOCK2	PLXNB3
Description		SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2	plexin B3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Synapse Assembly Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Regulation Of Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell Motility	Positive Regulation Of Endothelial Cell Proliferation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Synapse Assembly Regulation Of Cell Shape Negative Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways			Other semaphorin interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Insulin-like growth factors ( 21216879) Response to antioxidants and zinc in age-related macular degeneration (disease progression) ( 33751636) Smoking behavior ( 22832964)
Interacting Genes		4 interacting genes: DSCR9 PLXNB3 SPOCK3 TES	10 interacting genes: ARHGEF11 BTBD3 CUL7 CUL9 DSCR9 HSPA13 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		9806	5365
HPRD ID		12146	02198
Ensembl ID		ENSG00000107742	ENSG00000198753
Uniprot IDs		Q92563	A8K920 Q9ULL4
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hydrolase Activity Negative Regulation Of Catalytic Activity Rho GDP-dissociation Inhibitor Binding Semaphorin Receptor Activity Semaphorin Receptor Complex Negative Regulation Of Lamellipodium Assembly Negative Regulation Of GTPase Activity Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Metalloendopeptidase Inhibitor Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Glycosaminoglycan Binding Regulation Of Catalytic Activity Extracellular Matrix Binding	Cullin-RING Ubiquitin Ligase Complex
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