KIAA0513 and HAX1

Number of citations of the paper that reports this interaction (PubMedID 17010949)
0

Data Source:
HPRD (two hybrid)

		KIAA0513	HAX1
Description		KIAA0513	HCLS1 associated protein X-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	P-body Nucleus Nuclear Envelope Transcription Regulator Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function		Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Signaling Adaptor Activity
	Biological Process		Mitochondrion Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion
Pathways
Drugs
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Amyotrophic lateral sclerosis ( 22959728) Dysphagia ( 26116289) Lateral ventricle temporal horn volume ( 31530798)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		4 interacting genes: APP HAX1 INTS4 WWC1	26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL WEE2-AS1 YWHAQ ZNF420
Entrez ID		9764	10456
HPRD ID		17192	12075
Ensembl ID		ENSG00000135709	ENSG00000143575
Uniprot IDs		O60268	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Regulation Of Type II Interferon Production Cell Activation Involved In Immune Response Amylin Binding Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Peptide Positive Regulation Of Type II Interferon Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Cytokine Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Plasmacytoid Dendritic Cell Differentiation Signaling Adaptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Plasmacytoid Dendritic Cell Activation Follicular B Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Gene Expression Regulation Of Spontaneous Synaptic Transmission Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II	Ceramide Floppase Activity Ceramide Translocation Cytosol Regulation Of Transport Sphingolipid Translocation Phosphatidylcholine Floppase Activity ABC-type Transporter Activity Intercellular Canaliculus Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Import Transmembrane Transporter Binding Dendritic Spine Maintenance ATPase-coupled Intramembrane Lipid Transporter Activity Regulation Of Interleukin-2 Production Homeostatic Process Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Regulation Of Calcium Ion Import Across Plasma Membrane RNA Polymerase I Complex Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Ceramide Transport Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Cytoplasm Negative Regulation Of Monoatomic Ion Transport Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Dendritic Spine Organization Response To Copper Ion Multicellular Organismal-level Homeostasis Positive Regulation Of Interleukin-2 Production Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Phospholipid Translocation ATPase-coupled Transmembrane Transporter Activity Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Transmembrane Transport Type 8 Metabotropic Glutamate Receptor Binding
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