KIAA0513 and WWC1

Number of citations of the paper that reports this interaction (PubMedID 17010949)
0

Data Source:
HPRD (two hybrid, in vivo)

		KIAA0513	WWC1
Description		KIAA0513	WW and C2 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function		Transcription Coactivator Activity Protein Binding Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Migration Establishment Of Cell Polarity Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Negative Regulation Of Organ Growth
Pathways			Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 22959728) Dysphagia ( 26116289) Lateral ventricle temporal horn volume ( 31530798)	Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)
Interacting Genes		4 interacting genes: APP HAX1 INTS4 WWC1	16 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK UBC WWC2 WWC3
Entrez ID		9764	23286
HPRD ID		17192	10033
Ensembl ID		ENSG00000135709	ENSG00000113645
Uniprot IDs		O60268	Q8IX03
PDB IDs			2Z0U 6FB4 6FD0 6FJC 6FJD
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Regulation Of Type II Interferon Production Cell Activation Involved In Immune Response Amylin Binding Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Peptide Positive Regulation Of Type II Interferon Production Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Cytokine Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Plasmacytoid Dendritic Cell Differentiation Signaling Adaptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Plasmacytoid Dendritic Cell Activation Follicular B Cell Differentiation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Gene Expression Regulation Of Spontaneous Synaptic Transmission Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Autophagosome Assembly
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