ZNF646 and PRKG1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ZNF646	PRKG1
Gene Name		zinc finger protein 646	protein kinase, cGMP-dependent, type I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation
Pathways			Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Asthma ( 21907864) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: C11orf30 MDFI NINL PRKG1 TRAF2 UBE2I	34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646
Entrez ID		9726	5592
HPRD ID		15886	08910
Ensembl ID		ENSG00000167395	ENSG00000185532
Uniprot IDs		O15015	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of SUMO Transferase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Binding Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Relaxation Of Vascular Smooth Muscle Positive Regulation Of Protein Homodimerization Activity CGMP-mediated Signaling Relaxation Of Smooth Muscle Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Platelet Aggregation Cellular Response To Nitric Oxide Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Regulation Of Cell-cell Adhesion Organelle Organization Negative Regulation Of Smooth Muscle Contraction Regulation Of Platelet Aggregation Trophoblast Giant Cell Differentiation Negative Regulation Of Platelet Activation Cellular Response To Stress Positive Regulation Of Catalytic Activity Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Protein Homodimerization Activity Positive Regulation Of MAPK Cascade Response To Stress Cellular Response To Reactive Nitrogen Species Positive Regulation Of Protein Kinase Activity Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Negative Regulation Of Muscle Contraction Regulation Of Cell Activation Relaxation Of Muscle Positive Regulation Of Kinase Activity Cytoplasmic Sequestering Of Protein	Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle
Tagcloud ?			1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?			1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?