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HLA-DQB1 and CD74
Number of citations of the paper that reports this interaction (PMID
16242130
)
2
Data Source:
HPRD
(in vivo)
HLA-DQB1
CD74
Gene Name
major histocompatibility complex, class II, DQ beta 1
CD74 molecule, major histocompatibility complex, class II invariant chain
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Lysosomal Membrane
Plasma Membrane
Endosome Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Golgi Membrane
Intracellular
Lysosomal Membrane
Multivesicular Body
Vacuole
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Macrophage Migration Inhibitory Factor Receptor Complex
NOS2-CD74 Complex
MHC Class II Protein Complex
Lysosomal Lumen
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
MHC Class II Receptor Activity
Peptide Antigen Binding
Beta-amyloid Binding
Cytokine Receptor Activity
Protein Binding
Cytokine Binding
MHC Class II Protein Complex Binding
Macrophage Migration Inhibitory Factor Binding
MHC Class II Protein Binding
MHC Class II Protein Binding, Via Antigen Binding Groove
Identical Protein Binding
Protein Binding Involved In Protein Folding
Nitric-oxide Synthase Binding
Biological Process
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
Humoral Immune Response Mediated By Circulating Immunoglobulin
Immune Response
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
T Cell Receptor Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Activation Of MAPK Activity
Prostaglandin Biosynthetic Process
Positive Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of Peptide Secretion
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Protein Complex Assembly
Intracellular Protein Transport
Defense Response
Signal Transduction
Cell Proliferation
Immunoglobulin Mediated Immune Response
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of B Cell Proliferation
Macrophage Migration Inhibitory Factor Signaling Pathway
Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
T Cell Selection
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Chaperone Mediated Protein Folding Requiring Cofactor
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
MHC class II antigen presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Asthma (
21804548
)
Celiac disease (
20190752
)
Crohn's disease (
23266558
)
Epstein-Barr virus immune response (EBNA-1) (
23326239
)
Follicular lymphoma (
20639881
21533074
)
Hepatitis B (
21750111
)
HPV seropositivity (
21896673
)
Hypothyroidism (
22493691
)
IgE levels (
23146381
)
Knee osteoarthritis (
20305777
)
Lymphoma (
23349640
)
Multiple sclerosis (
20453840
)
Multiple sclerosis (OCB status) (
23472185
)
Nephropathy (
21399633
)
Nodular sclerosis Hodgkin lymphoma (
22086417
)
Primary biliary cirrhosis (
19458352
20639880
)
Prostate cancer (
23535732
)
Pulmonary function (
21946350
)
Pulmonary function (interaction) (
23284291
)
Systemic sclerosis (
20383147
21779181
)
Ulcerative colitis (
23128233
19122664
)
Protein-Protein Interactions
4 interactors:
CD4
CD74
HLA-DQA2
INS
14 interactors:
APP
CD1D
CD44
CTSF
CTSL
HADHA
HLA-DMA
HLA-DMB
HLA-DPA1
HLA-DPB1
HLA-DQA1
HLA-DQB1
HLA-DRA
MIF
Entrez ID
3119
972
HPRD ID
05054
00825
Ensembl ID
ENSG00000179344
ENSG00000019582
Uniprot IDs
P01920
Q5SU54
Q5Y7A9
Q5Y7D3
Q5Y7D6
P04233
PDB IDs
1JK8
1NBN
1S9V
1UVQ
2NNA
4GG6
1A6A
1ICF
1IIE
1L3H
1MUJ
3PDO
3PGC
3PGD
3QXA
3QXD
4AEN
4AH2
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Positive Regulation Of T Cell Activation
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Immune System Process
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Defense Response
Positive Regulation Of Cytokine Production
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of Cellular Amino Acid Metabolic Process
T Cell Selection
Lymphocyte Activation
Positive Regulation Of Protein Kinase Activity
Regulation Of Cell Activation
Leukocyte Activation
Positive Regulation Of Kinase Activity
Regulation Of Cellular Ketone Metabolic Process
Single Organismal Cell-cell Adhesion
Regulation Of Cytokine Production
Positive Regulation Of Transferase Activity
T Cell Costimulation
Regulation Of Cell Adhesion
Immune System Process
Positive Regulation Of Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Cell Activation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Regulation Of Protein Kinase Activity
T Cell Receptor Signaling Pathway
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Induction By Virus Of Host Cell-cell Fusion
Macrophage Migration Inhibitory Factor Signaling Pathway
Protein Palmitoleylation
Positive Regulation Of Phosphorylation
Antigen Receptor-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation
Positive Regulation Of Homotypic Cell-cell Adhesion
Antigen Processing And Presentation Of Peptide Antigen
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Activation
Immune Response
Positive Regulation Of T Cell Activation
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Positive Regulation Of Immune Response
Immune System Process
Regulation Of Cell Activation
Regulation Of T Cell Activation
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Cell Adhesion
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Regulation Of Immune System Process
Defense Response
Response To Interferon-gamma
T Cell Costimulation
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
T Cell Receptor Signaling Pathway
Positive Regulation Of Lymphocyte Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Antigen Receptor-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of T Cell Proliferation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cellular Response To Cytokine Stimulus
Regulation Of T Cell Proliferation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Cytokine
Response To Organic Substance
Response To Stress
Response To Stimulus
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Response To Organic Substance
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Cell Proliferation
Tagcloud
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
map2k1
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
socs5
targetable
uniform
v600e
Tagcloud (Difference)
?
actionable
adenocarcinomas
akt1
alk
braf
capture
ccdc6
clip4
deemed
driver
fusions
g719a
genomic
introns
kif5b
map2k1
nccn
ngs
nras
pack
pik3ca
profiling
rearranged
ret
ros1
socs5
targetable
uniform
v600e
Tagcloud (Intersection)
?