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HLA-DQB1 and HLA-DQA2
Number of citations of the paper that reports this interaction (PMID
9036956
)
2
Data Source:
HPRD
(in vitro, in vivo)
HLA-DQB1
HLA-DQA2
Gene Name
major histocompatibility complex, class II, DQ beta 1
major histocompatibility complex, class II, DQ alpha 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Lysosomal Membrane
Plasma Membrane
Endosome Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Golgi Membrane
Lysosomal Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Endosome Membrane
ER To Golgi Transport Vesicle Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
MHC Class II Receptor Activity
Peptide Antigen Binding
MHC Class II Receptor Activity
Biological Process
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
Humoral Immune Response Mediated By Circulating Immunoglobulin
Immune Response
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
T Cell Receptor Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Immune Response
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
T Cell Receptor Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Pathways
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Drugs
Diseases
GWAS
Asthma (
21804548
)
Celiac disease (
20190752
)
Crohn's disease (
23266558
)
Epstein-Barr virus immune response (EBNA-1) (
23326239
)
Follicular lymphoma (
20639881
21533074
)
Hepatitis B (
21750111
)
HPV seropositivity (
21896673
)
Hypothyroidism (
22493691
)
IgE levels (
23146381
)
Knee osteoarthritis (
20305777
)
Lymphoma (
23349640
)
Multiple sclerosis (
20453840
)
Multiple sclerosis (OCB status) (
23472185
)
Nephropathy (
21399633
)
Nodular sclerosis Hodgkin lymphoma (
22086417
)
Primary biliary cirrhosis (
19458352
20639880
)
Prostate cancer (
23535732
)
Pulmonary function (
21946350
)
Pulmonary function (interaction) (
23284291
)
Systemic sclerosis (
20383147
21779181
)
Ulcerative colitis (
23128233
19122664
)
Alopecia areata (
20596022
)
Asthma (
21804548
)
Crohn's disease (
21102463
23266558
)
Hypothyroidism (
22493691
)
IgE levels (
23146381
22075330
)
IgG glycosylation (
23382691
)
Knee osteoarthritis (
20305777
)
Lymphoma (
23349640
)
Multiple sclerosis (OCB status) (
23472185
)
Narcolepsy (
20711174
)
Pulmonary function (interaction) (
23284291
)
Rheumatoid arthritis (
18668548
)
Systemic lupus erythematosus (
23053960
21408207
)
Type 2 diabetes (
22693455
)
Protein-Protein Interactions
4 interactors:
CD4
CD74
HLA-DQA2
INS
3 interactors:
CD4
HLA-DQB1
INS
Entrez ID
3119
3118
HPRD ID
05054
09982
Ensembl ID
ENSG00000179344
Uniprot IDs
P01920
Q5SU54
Q5Y7A9
Q5Y7D3
Q5Y7D6
P01906
PDB IDs
1JK8
1NBN
1S9V
1UVQ
2NNA
4GG6
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Positive Regulation Of T Cell Activation
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Immune System Process
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Defense Response
Positive Regulation Of Cytokine Production
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of Cellular Amino Acid Metabolic Process
T Cell Selection
Lymphocyte Activation
Positive Regulation Of Protein Kinase Activity
Regulation Of Cell Activation
Leukocyte Activation
Positive Regulation Of Kinase Activity
Regulation Of Cellular Ketone Metabolic Process
Single Organismal Cell-cell Adhesion
Regulation Of Cytokine Production
Positive Regulation Of Transferase Activity
T Cell Costimulation
Regulation Of Cell Adhesion
Immune System Process
Positive Regulation Of Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Cell Activation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Regulation Of Protein Kinase Activity
T Cell Receptor Signaling Pathway
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Induction By Virus Of Host Cell-cell Fusion
Macrophage Migration Inhibitory Factor Signaling Pathway
Protein Palmitoleylation
Positive Regulation Of Phosphorylation
Antigen Receptor-mediated Signaling Pathway
T Cell Costimulation
Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Induction By Virus Of Host Cell-cell Fusion
Protein Palmitoleylation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune System Process
Defense Response
Positive Regulation Of T Cell Activation
Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Glycogen Catabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Negative Regulation Of NAD(P)H Oxidase Activity
T Cell Aggregation
T Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Lymphocyte Aggregation
Leukocyte Aggregation
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Cytokine Production
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune System Process
Regulation Of Brown Fat Cell Differentiation
Regulation Of NAD(P)H Oxidase Activity
Negative Regulation Of Feeding Behavior
Regulation Of Lymphocyte Activation
Regulation Of Cellular Amino Acid Metabolic Process
Lymphocyte Activation
Positive Regulation Of Respiratory Burst
Negative Regulation Of Vasodilation
Negative Regulation Of Protein Oligomerization
Regulation Of Glycogen Catabolic Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Regulation Of Cell Activation
Leukocyte Activation
Positive Regulation Of Kinase Activity
Regulation Of Cellular Ketone Metabolic Process
Regulation Of Respiratory Burst
Single Organismal Cell-cell Adhesion
Regulation Of Cytokine Production
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Tagcloud (Intersection)
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