PUM1 and EIF5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PUM1	EIF5
Gene Name		pumilio RNA-binding family member 1	eukaryotic translation initiation factor 5
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Poly(A) RNA Binding	Translation Initiation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Translation Post-Golgi Vesicle-mediated Transport Membrane Organization	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS			Red blood cell traits ( 23222517)
Protein-Protein Interactions		4 interactors: ATXN1 EIF5 PRR12 SMAD1	14 interactors: APP CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 NCBP2 NRGN PUM1
Entrez ID		9698	1983
HPRD ID		06230	03417
Ensembl ID		ENSG00000134644	ENSG00000100664
Uniprot IDs		B4DG92 E7EWT3 Q14671 Q5T1Z8	P55010 Q6IBU0
PDB IDs		1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P	2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?		Primary MiRNA Processing Osteoblast Fate Commitment Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Posttranscriptional Regulation Of Gene Expression SMAD Protein Complex Assembly RNA Processing Mesodermal Cell Fate Commitment Cardiac Muscle Cell Proliferation Tube Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To BMP Stimulus Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Gene Expression Mesodermal Cell Differentiation Cellular Macromolecule Biosynthetic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Macromolecule Biosynthetic Process Cardiac Muscle Tissue Growth Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Dendrite Morphogenesis Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Cartilage Development Posttranscriptional Gene Silencing Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Apoptotic Process Lung Alveolus Development Positive Regulation Of Dendrite Development Visual Learning Gene Silencing By RNA Visual Behavior Regulation Of Dendrite Morphogenesis Biosynthetic Process Positive Regulation Of Osteoblast Differentiation Regulation Of Gene Expression Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Translational Initiation Response To DsRNA Regulation Of Postsynaptic Membrane Potential BMP Signaling Pathway Midbrain Development Associative Learning Mesoderm Formation Regulation Of Cartilage Development Embryonic Pattern Specification Mesoderm Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process	Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Translation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Gene Expression MRNA 3'-end Processing Protein Metabolic Process RNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Formation Of Translation Preinitiation Complex Ribonucleoprotein Complex Assembly Cellular Macromolecular Complex Assembly Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Axon Guidance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Processing Collateral Sprouting In Absence Of Injury Cytokine-mediated Signaling Pathway Male Germ Cell Proliferation Regulation Of Metabolic Process Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Axonogenesis Cellular Component Assembly Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis MRNA Catabolic Process Axon Choice Point Recognition Axon Development RNA Processing Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cytoplasmic Translational Initiation Positive Regulation Of Glucokinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Chemotaxis Adiponectin-activated Signaling Pathway
Tagcloud ?		adequate alas1 arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative regardless secretory softwares standards taqman trim27 ube2d2	40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic frame homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine reading similarity tagged tif35p transiently trna u20s ydr
Tagcloud (Difference) ?		adequate alas1 arf1 candidate eif2b1 fbxw2 genorm gusb housekeeping hprt1 hysterectomy ideal leiomyoma menopausal menstrual mrpl19 myometrial myometrium normalization normfinder phases proliferative regardless secretory softwares standards taqman trim27 ube2d2	40s 429c cdna cdnas cloning deduced eif3 encodes eukaryotic frame homogeneity identity incorporated initiator laboratories lysates methionyl mr35 multisubunit p42 polyhistidine reading similarity tagged tif35p transiently trna u20s ydr
Tagcloud (Intersection) ?