PUM1 and MIR19B2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PUM1	MIR19B2
Description		pumilio RNA binding family member 1	microRNA 19b-2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Axon	RISC Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding
	Biological Process	Regulation Of Translation Spermatogenesis Adult Locomotory Behavior Post-transcriptional Regulation Of Gene Expression Post-transcriptional Gene Silencing Cell Differentiation MiRNA Processing Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		48 interacting genes: ATXN1 COPS5 EIF5 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR15B MIR17 MIR18B MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR25 MIR29A MIR29C MIR34A MIR7-1 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRR12 SMAD1	93 interacting genes: ADARB1 AIMP1 AIMP2 AQR C1QBP CELF1 CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FUS HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PATL1 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBMS2 RTCA RTCB SART3 SF1 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2B TRIM25 U2SURP UPF1 USP36 UTP20 YBX1 YBX3 ZFR ZNF346 ZNF385A
Entrez ID		9698	406981
HPRD ID		06230
Ensembl ID		ENSG00000134644	ENSG00000284107
Uniprot IDs		Q14671
PDB IDs		1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Locomotion Regulation Of MRNA Stability Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Communication	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Nucleus MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex Spliceosomal Complex MRNA 3'-UTR Binding Catalytic Step 2 Spliceosome Regulation Of Translation MiRNA Binding Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity RNA Stabilization TRNA Aminoacylation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability MRNA Stabilization Ligase Activity Regulation Of RNA Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Nucleolus Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Helicase Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation
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