PUM1 and MIR138-1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PUM1	MIR138-1
Description		pumilio RNA binding family member 1	microRNA 138-1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Axon	Cytoplasm RISC Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Translation Spermatogenesis Adult Locomotory Behavior Post-transcriptional Regulation Of Gene Expression Post-transcriptional Gene Silencing Cell Differentiation MiRNA Processing Regulation Of MRNA Stability Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Chromosome Segregation Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Destabilization Positive Regulation Of RIG-I Signaling Pathway Positive Regulation Of MiRNA-mediated Gene Silencing	Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Population Proliferation Negative Regulation Of Lipid Storage Negative Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Vasodilation Negative Regulation Of Canonical NF-kappaB Signal Transduction Plasma Membrane Raft Assembly Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Inflammatory Response Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Adipose Tissue Development Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)	Schizophrenia ( 30285260)
Interacting Genes		48 interacting genes: ATXN1 COPS5 EIF5 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR143 MIR145 MIR15B MIR17 MIR18B MIR199A1 MIR199A2 MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR21 MIR214 MIR25 MIR29A MIR29C MIR34A MIR7-1 MIR9-3 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRR12 SMAD1	67 interacting genes: ADARB1 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LIN28A LRPPRC MARS1 MATR3 NONO NUDT16L1 NUDT21 PDCD11 PRMT1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBM14 RBM4 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TENT2 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3
Entrez ID		9698	406929
HPRD ID		06230
Ensembl ID		ENSG00000134644	ENSG00000207954
Uniprot IDs		Q14671
PDB IDs		1IB2 1M8W 1M8X 1M8Y 1M8Z 2YJY 3BSB 3BSX 3Q0L 3Q0M 3Q0N 3Q0O 3Q0P 5YKH 5YKI
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Regulation Of Angiogenesis Regulation Of Metabolic Process Negative Regulation Of Cell Migration Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Locomotion Regulation Of MRNA Stability Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Communication	RNA Binding RNA Processing Nucleic Acid Binding RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Nucleus Ribonucleoprotein Complex Nucleoplasm Spliceosomal Complex Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Aminoacyl-tRNA Synthetase Multienzyme Complex MiRNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Translation Cytoplasmic Stress Granule Regulation Of MRNA Processing Positive Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process MRNA Stabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity
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