PRORP and SRP54

Data Source: HiPPIP (Novel)

		PRORP	SRP54
Name		protein only RNase P catalytic subunit	signal recognition particle 54
Structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck Signal Recognition Particle Ribonucleoprotein Complex
	Molecular Function	Nuclease Activity Ribonuclease P Activity Hydrolase Activity Metal Ion Binding	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding Hydrolase Activity GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding
	Biological Process	TRNA 5'-leader Removal TRNA Processing Mitochondrial TRNA 5'-end Processing	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion rRNA processing in the mitochondrion	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
GWAS		No GWAS studies recorded	Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Immunoglobulin light chain (AL) amyloidosis ( 28025584 )
Novel Interactors		1 novel interactors: SRP54	6 novel interactors: EGLN3 KLK12 PRORP RALGAPA1 STAB1 TKTL1
Interacting Genes		1 interacting genes: OGT	4 interacting genes: CEBPA OGT RNPS1 SRP19
Entrez ID		9692	6729
HPRD ID		18711	05330
Ensembl ID		ENSG00000100890	ENSG00000100883
Uniprot IDs		O15091	G3V480 P61011
PDB IDs		4ROU 4XGL 4XGM 7ONU 8CBK	1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32 7NFX 7QWQ
GO Terms Enriched among Interactors		Signal Recognition Particle Endoplasmic Reticulum Signal Peptide Binding 7S RNA Binding SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Signal Recognition Particle, Endoplasmic Reticulum Targeting SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Exocrine Pancreas Development SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Transcription By Glucose NSL Complex Cotranslational Protein Targeting To Membrane Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity Sin3-type Complex Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Granulocyte Differentiation Protein Targeting To ER Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Intracellular Protein Transmembrane Transport Regulation Of Necroptotic Process Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Rac Protein Signal Transduction Ribonucleoprotein Complex Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cellular Response To Nutrient Regulation Of Programmed Necrotic Cell Death Protein Transmembrane Transport Protein Targeting To Membrane GDP Binding Neutrophil Chemotaxis Granulocyte Chemotaxis Protein-containing Complex Organization Protein-containing Complex Assembly Neutrophil Migration Mitophagy Protein Localization To Lysosome Circadian Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Glucose Stimulus Regulation Of Stem Cell Population Maintenance	None