SRP54 and KLK12

		SRP54	KLK12
Description		signal recognition particle 54	kallikrein related peptidase 12
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck Signal Recognition Particle Ribonucleoprotein Complex	Extracellular Region Extracellular Space Secretory Granule
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding Hydrolase Activity GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER	Proteolysis Protein Maturation
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	Formation of the cornified envelope
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		4 interacting genes: CEBPA OGT RNPS1 SRP19
Entrez ID		6729	43849
HPRD ID		05330	05705
Ensembl ID		ENSG00000100883	ENSG00000186474
Uniprot IDs		G3V480 P61011	A0A024R4M4 B9EGA9 Q49AM7 Q9UKR0
PDB IDs		1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32 7NFX 7QWQ
Enriched GO Terms of Interacting Partners?			Signal Recognition Particle Exocrine Pancreas Development Endoplasmic Reticulum Signal Peptide Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation 7S RNA Binding SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Intracellular Protein Transmembrane Transport Granulocyte Differentiation Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Ribonucleoprotein Complex Binding Neutrophil Chemotaxis Protein Transmembrane Transport Protein Targeting To Membrane GDP Binding Granulocyte Chemotaxis Neutrophil Migration Granulocyte Migration Myeloid Leukocyte Migration Leukocyte Chemotaxis Myeloid Leukocyte Differentiation Cell Chemotaxis Establishment Of Protein Localization To Membrane Protein Targeting Leukocyte Migration Myeloid Cell Differentiation Gland Development GTPase Activity Establishment Of Protein Localization To Organelle Chemotaxis Leukocyte Differentiation Locomotion GTP Binding Ribonucleoprotein Complex Nuclear Speck
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