SRP54 and STAB1

		SRP54	STAB1
Description		signal recognition particle 54	stabilin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck Signal Recognition Particle Ribonucleoprotein Complex	Plasma Membrane Membrane Endocytic Vesicle Membrane
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding Hydrolase Activity GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Protein-disulfide Reductase Activity Low-density Lipoprotein Particle Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER	Endocytosis Receptor-mediated Endocytosis Inflammatory Response Cell Adhesion Cell-cell Signaling Negative Regulation Of Angiogenesis Defense Response To Bacterium
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	Scavenging by Class H Receptors
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immunoglobulin light chain (AL) amyloidosis ( 28025584)	A body shape index ( 34021172) Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Colon cancer ( 33632709) Cortical surface area (MOSTest) ( 32665545) Distal colorectal cancer ( 33632709) Diverticular disease ( 30177863) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 31562340) Hematocrit ( 27863252) Hodgkin's lymphoma ( 34216518) Intelligence (MTAG) ( 29326435) Iron status biomarkers (ferritin levels) ( 33536631) Parkinson's disease ( 28892059) Schizophrenia ( 29483656 25056061 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		4 interacting genes: CEBPA OGT RNPS1 SRP19	8 interacting genes: CHID1 DYRK1A GGA1 GGA2 GGA3 NUFIP2 ORC5 PIK3R2
Entrez ID		6729	23166
HPRD ID		05330	09778
Ensembl ID		ENSG00000100883	ENSG00000010327
Uniprot IDs		G3V480 P61011	Q9NY15
PDB IDs		1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32 7NFX 7QWQ
Enriched GO Terms of Interacting Partners?			Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Surface Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Trans-Golgi Network Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Localization Within Membrane Intracellular Protein Transport Protein Localization To Plasma Membrane Early Endosome Membrane Regulation Of Amyloid-beta Formation Protein Transport Protein Localization To Cell Periphery Regulation Of Amyloid Precursor Protein Catabolic Process Histone H3T45 Kinase Activity Establishment Of Protein Localization Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Protein Localization To Membrane Regulation Of Amide Metabolic Process Actin Filament Ribonucleoprotein Complex Regulation Of Supramolecular Fiber Organization Endoplasmic Reticulum Signal Peptide Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Heterochromatin Formation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Origin Recognition Complex Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Intracellular Protein Localization Regulation Of Actin Filament Length 1-phosphatidylinositol-3-kinase Regulator Activity Signal Recognition Particle SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Box C/D Methylation Guide SnoRNP Complex Regulation Of Microvillus Length Anion Binding Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization 7S RNA Binding
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