SRP54 and SRP19

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		SRP54	SRP19
Name		signal recognition particle 54	signal recognition particle 19
Structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck Signal Recognition Particle Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Body Signal Recognition Particle Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding Hydrolase Activity GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding	RNA Binding Protein Binding 7S RNA Binding Ribosome Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
GWAS		Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Immunoglobulin light chain (AL) amyloidosis ( 28025584 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: EGLN3 KLK12 PRORP RALGAPA1 STAB1 TKTL1	2 novel interactors: AP3S1 ATG12
Interacting Genes		4 interacting genes: CEBPA OGT RNPS1 SRP19	9 interacting genes: APP CEBPA IPO5 IPO7 IPO8 KPNA1 MAPK8IP2 SRP54 TNPO1
Entrez ID		6729	6728
HPRD ID		05330	01644
Ensembl ID		ENSG00000100883	ENSG00000153037
Uniprot IDs		G3V480 P61011	A0A087WYR0 A0A2U3TZN1 P09132
PDB IDs		1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32 7NFX 7QWQ	1JID 1MFQ 1RY1 2J37 3KTV 4P3E 5M73 7NFX 7QWQ
GO Terms Enriched among Interactors		None	Intracellular Protein Transport Protein Import Into Nucleus Import Into Nucleus Establishment Of Protein Localization To Organelle Protein Localization To Nucleus Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Nuclear Pore Small GTPase Binding Intracellular Protein Localization Protein Localization To Organelle Mating Behavior NLS-bearing Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Granulocyte Differentiation Reproductive Behavior Modulation Of Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Learning Or Memory Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cognition Protein-containing Complex Acetylcholine Receptor Activator Activity Axo-dendritic Transport Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Positive Regulation Of Viral Translation Regulation Of Defense Response PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development