NUP93 and MPPED2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		NUP93	MPPED2
Name		nucleoporin 93	metallophosphoesterase domain containing 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Centrosome Cytosol Membrane Nuclear Membrane Nuclear Periphery	None
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Nucleotide Binding Protein Binding Phosphoric Diester Hydrolase Activity AMP Binding Hydrolase Activity GMP Binding Manganese Ion Binding Metal Ion Binding
	Biological Process	Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Envelope Organization Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Positive Regulation Of SMAD Protein Signal Transduction	None
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Gambling ( 22780124 ) HDL cholesterol ( 20031564 ) HDL cholesterol levels ( 26763881 32203549 ) Potassium levels ( 29403010 )	Adventurousness ( 30643258 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Asthma ( 27611488 ) Automobile speeding propensity ( 30643258 ) Blood urea nitrogen levels ( 29403010 ) Chronic kidney disease ( 22479191 26831199 ) Chronotype ( 30696823 ) Creatinine levels ( 29403010 ) Dental caries ( 21940522 ) Estimated glomerular filtration rate ( 31015462 30604766 ) Falling risk ( 32999390 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Major depressive disorder ( 27479909 ) Medication use (diuretics) ( 31015401 ) Migraine ( 27322543 ) Morning person ( 30696823 ) Pit-and-Fissure caries ( 24556642 ) PR interval ( 32439900 ) Refractive error ( 32231278 ) Renal function-related traits (eGRFcrea) ( 22797727 ) Renal function-related traits (sCR) ( 22797727 ) Serum uric acid levels ( 30993211 29403010 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Systolic blood pressure ( 30578418 ) Triglyceride levels ( 32203549 ) Urate levels ( 31578528 )
Novel Interactors		None recorded	3 novel interactors: BDNF GCH1 PAX6
Interacting Genes		10 interacting genes: AP5Z1 CEBPA GRSF1 MPPED2 NDC1 NUP205 NUP35 OPCML PLA2G6 TMEM100	14 interacting genes: BEX4 CAGE1 FAM72A HOOK2 IKZF1 MBD3L1 NOTCH3 NUP93 POMP RIBC1 RUNX1 RXRG TRIP13 VAC14
Entrez ID		9688	744
HPRD ID		14854	02947
Ensembl ID		ENSG00000102900	ENSG00000066382
Uniprot IDs		Q8N1F7	Q15777
PDB IDs		5IJN 5IJO 7MW0 7MW1 7PER 7R5J 7R5K	Not available
GO Terms Enriched among Interactors		Nuclear Pore Organization Structural Constituent Of Nuclear Pore Nucleus Organization Nuclear Pore Complex Assembly Nuclear Pore Pore Complex Assembly MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Envelope Nuclear Transport Nucleocytoplasmic Transport Nuclear Membrane RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Nuclear Pore Transmembrane Ring Response To Vitamin B2 C/EBP Complex AP-5 Adaptor Complex GMP Binding CHOP-C/EBP Complex Positive Regulation Of Mitochondrial RNA Catabolic Process Nuclear Pore Inner Ring Notch Signaling Pathway White Fat Cell Proliferation Phosphatidylethanolamine Catabolic Process Protein Transport Arterial Endothelial Cell Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Cardiolipin Acyl-chain Remodeling AP-type Membrane Coat Adaptor Complex Nuclear Pore Localization	None