NUP93 and AP5Z1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUP93	AP5Z1
Description		nucleoporin 93	adaptor related protein complex 5 subunit zeta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Centrosome Cytosol Membrane Nuclear Membrane Nuclear Periphery	Nucleus Nucleoplasm Cytoplasm Lysosome Late Endosome Nuclear Speck AP-type Membrane Coat Adaptor Complex AP-5 Adaptor Complex
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Protein Binding
	Biological Process	Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Envelope Organization Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Positive Regulation Of SMAD Protein Signal Transduction	Autophagosome Assembly Double-strand Break Repair Via Homologous Recombination DNA Repair Intracellular Protein Transport Autophagy DNA Damage Response Golgi Organization Lysosome Organization Gene Expression Protein Transport Vesicle-mediated Transport Endosomal Transport Late Endosome To Golgi Transport Axon Development Lysosomal Protein Catabolic Process
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Gambling ( 22780124) HDL cholesterol ( 20031564) HDL cholesterol levels ( 26763881 32203549) Potassium levels ( 29403010)	Parental extreme longevity (95 years and older) ( 27015805)
Interacting Genes		10 interacting genes: AP5Z1 CEBPA GRSF1 MPPED2 NDC1 NUP205 NUP35 OPCML PLA2G6 TMEM100	2 interacting genes: MDFI NUP93
Entrez ID		9688	9907
HPRD ID		14854	13801
Ensembl ID		ENSG00000102900	ENSG00000242802
Uniprot IDs		Q8N1F7	O43299
PDB IDs		5IJN 5IJO 7MW0 7MW1 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Nuclear Pore Organization Structural Constituent Of Nuclear Pore Nucleus Organization Nuclear Pore Complex Assembly Nuclear Pore Pore Complex Assembly MRNA Transport RNA Transport Nucleobase-containing Compound Transport Nuclear Envelope Nuclear Transport Nucleocytoplasmic Transport Nuclear Membrane RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Nuclear Pore Transmembrane Ring Response To Vitamin B2 C/EBP Complex AP-5 Adaptor Complex GMP Binding CHOP-C/EBP Complex Positive Regulation Of Mitochondrial RNA Catabolic Process Nuclear Pore Inner Ring Notch Signaling Pathway White Fat Cell Proliferation Phosphatidylethanolamine Catabolic Process Protein Transport Arterial Endothelial Cell Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Cardiolipin Acyl-chain Remodeling AP-type Membrane Coat Adaptor Complex Nuclear Pore Localization	Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Cell Differentiation Involved In Embryonic Placenta Development Nuclear Envelope Organization Poly(A)+ MRNA Export From Nucleus Pore Complex Assembly Structural Constituent Of Nuclear Pore Nuclear Pore Complex Assembly Nuclear Pore Organization Nuclear Periphery Transcription Regulator Inhibitor Activity Protein Sequestering Activity Positive Regulation Of SMAD Protein Signal Transduction
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