CLCA2 and ITGB4

Number of citations of the paper that reports this interaction (PMID 12110680)
21

Data Source:
HPRD (in vitro, in vivo)

		CLCA2	ITGB4
Gene Name		chloride channel accessory 2	integrin, beta 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Cell Junction	Basement Membrane Plasma Membrane Integrin Complex Basal Plasma Membrane Cell Surface Hemidesmosome Cell Leading Edge Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Chloride Channel Activity Metallopeptidase Activity Ligand-gated Ion Channel Activity Metal Ion Binding	G-protein Coupled Receptor Binding Receptor Activity Protein Binding
	Biological Process	Proteolysis Transport Cell Adhesion Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport	Autophagy Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly Nail Development Skin Development Filopodium Assembly Mesodermal Cell Differentiation Digestive Tract Development Cell Motility Renal System Development Amelogenesis
Pathways		Ion channel transport Stimuli-sensing channels Orphan transporters	Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ITGB4	23 interactors: ALOX12 ATXN1 CLCA1 CLCA2 COL17A1 DST EIF6 ERBB2 ERBB2IP FYN GRB2 ITGA6 MET PLEC PRKCA PRKCD PTK2 SHC1 SREBF2 VIM YES1 YWHAB YWHAQ
Entrez ID		9635	3691
HPRD ID		04923	00946
Ensembl ID		ENSG00000137975	ENSG00000132470
Uniprot IDs		Q9UQC9	P16144
PDB IDs			1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A
Enriched GO Terms of Interacting Partners?		Nail Development Hemidesmosome Assembly Amelogenesis Filopodium Assembly Mesodermal Cell Differentiation Cell-substrate Junction Assembly Mesoderm Formation Mesoderm Morphogenesis Odontogenesis Of Dentin-containing Tooth Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Odontogenesis Digestive Tract Development Mesoderm Development Digestive System Development Autophagy Cell-matrix Adhesion Gastrulation Cell Junction Assembly Limb Development Cell-substrate Adhesion Skin Development Cell Projection Assembly Renal System Development Extracellular Matrix Organization Extracellular Structure Organization Urogenital System Development	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Cellular Response To Fibroblast Growth Factor Stimulus Hemidesmosome Assembly Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Response To Growth Factor Wound Healing Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Blood Coagulation Hemostasis Locomotion Immune Response-regulating Signaling Pathway Platelet Activation Protein Autophosphorylation Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Chemotaxis Axon Guidance Leukocyte Migration Cell Motility Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Cell-substrate Junction Assembly Regulation Of Cell Activation Programmed Cell Death Cell Death Death Cellular Response To Peptide Hormone Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Organic Substance Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Platelet Aggregation Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 magi1 manifestations nodosum pcombined phenotypes replicated structuring variants	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		01x10 27x10 2q24 2x10 3x10 94x10 ancestry bowel complicated comprising course crohn erythema european extra genotyped gwas gwass location loci ly75 magi1 manifestations nodosum pcombined phenotypes replicated structuring variants	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?