SLC39A13

Description		solute carrier family 39 member 13
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Protein Homodimerization Activity Metal Ion Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Metal Ion Transport Brown Fat Cell Differentiation Transmembrane Transport Connective Tissue Development Zinc Ion Transmembrane Transport
Pathways
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood urea nitrogen levels ( 31152163) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163) Diastolic blood pressure ( 27618452 28739976) Estimated glomerular filtration rate ( 31152163 31015462) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hip circumference ( 25673412) Lacunar stroke ( 33773637) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Refractive error ( 32231278) Systolic blood pressure ( 30578418 28739976 27618452) Waist circumference ( 25673412)
Interacting Genes		9 interacting genes: CD40 CREB3 F2RL1 MAPK8IP2 OPRM1 PGRMC2 REL SLC16A2 TCF4
Entrez ID		91252
HPRD ID		12287
Ensembl ID		ENSG00000165915
Uniprot IDs		G3V1B2 Q96H72
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAPK Cascade Positive Regulation Of Positive Chemotaxis G-protein Alpha-subunit Binding G-protein Beta-subunit Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MAPK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Deacetylase Activity Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Protein Secretion Neuronal Cell Body Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Communication Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Intracellular Signal Transduction Positive Regulation Of Signaling Response To Cobalamin Positive Regulation Of RNA Metabolic Process Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cellular Response To Morphine DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Thyroid-stimulating Hormone Secretion Beta-catenin-TCF7L2 Complex Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Migration Leukocyte Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Erythropoietin Inflammatory Response Cellular Response To Erythropoietin Negative Regulation Of Secretion By Cell
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