PPDPF and CTSC

Number of citations of the paper that reports this interaction (PubMedID 34975328)
48

Data Source:
BioGRID (two hybrid)

		PPDPF	CTSC
Description		pancreatic progenitor cell differentiation and proliferation factor	cathepsin C
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Lysosome Endoplasmic Reticulum Lumen Centrosome Membrane COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function		Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Dipeptidyl-peptidase Activity Peptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity Phosphatase Binding Chloride Ion Binding Identical Protein Binding Protein-folding Chaperone Binding
	Biological Process	Liver Development Cell Differentiation TOR Signaling TORC1 Signaling	T Cell Mediated Cytotoxicity Proteolysis Apoptotic Process Immune Response Negative Regulation Of Myelination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Microglial Cell Activation Positive Regulation Of Apoptotic Signaling Pathway
Pathways			COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Neutrophil degranulation
Drugs
Diseases			Papillon-Lefevre syndrome Haim-Munk syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Estimated glomerular filtration rate ( 31152163) Prostate cancer ( 23535732) Serum metabolite levels ( 33031748)	Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		11 interacting genes: BABAM2 CTSC DDB1 DNAJB1 GLMN MT2A PLSCR1 PRMT1 RIPK1 RPTOR TRIP6	5 interacting genes: CAPN1 CTSL PPDPF USP2-AS1 XRN2
Entrez ID		79144	1075
HPRD ID		12750	03841
Ensembl ID		ENSG00000125534	ENSG00000109861
Uniprot IDs		Q9H3Y8	P53634
PDB IDs			1K3B 2DJF 2DJG 3PDF 4CDC 4CDD 4CDE 4CDF 4OEL 4OEM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Cell Death Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Cytoplasm Regulation Of Signal Transduction Programmed Cell Death Regulation Of Immune System Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Cellular Response To Stress Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Myeloid Cell Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Translational Initiation Positive Regulation Of Gene Expression Protein Localization To Lysosome GATOR1 Complex Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation TORC1 Signaling Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of TORC1 Signaling Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Viral Genome Replication Protein-containing Complex Binding DNA Damage Response Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition TOR Signaling Cellular Response To Amino Acid Stimulus Lead Ion Binding Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Hepatocyte Growth Factor Receptor Binding Positive Regulation Of TOR Signaling Chromatin Organization Protein Localization To Vacuole Protein-folding Chaperone Binding Regulation Of Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Protein Folding Phosphatidylserine Biosynthetic Process Mercury Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface	Calpain Complex Mammary Gland Involution Cysteine-type Peptidase Activity Elastin Metabolic Process Endolysosome Lumen Macrophage Apoptotic Process Elastin Catabolic Process Serpin Family Protein Binding Fusion Of Virus Membrane With Host Plasma Membrane Chromaffin Granule Fusion Of Virus Membrane With Host Endosome Membrane Enkephalin Processing Transcription Termination Site Sequence-specific DNA Binding 5'-3' RNA Exonuclease Activity NMDA Selective Glutamate Receptor Signaling Pathway Inflammatory Cell Apoptotic Process Macromolecule Catabolic Process Termination Of RNA Polymerase II Transcription Self Proteolysis 5'-3' Exonuclease Activity Calcium-dependent Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Receptor-mediated Endocytosis Of Virus By Host Cell Proteoglycan Binding Endocytosis Involved In Viral Entry Into Host Cell Myeloid Cell Apoptotic Process Receptor Catabolic Process Endocytic Vesicle Lumen DNA-templated Transcription Termination Peptidase Activity Response To Thyroid Hormone CD4-positive, Alpha-beta T Cell Lineage Commitment Protein Autoprocessing Alpha-beta T Cell Lineage Commitment Hydrolase Activity Lysosome CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Ionotropic Glutamate Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding T Cell Lineage Commitment Glycoprotein Catabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Aggresome 3'-5'-RNA Exonuclease Activity Catabolic Process Ligand-gated Ion Channel Signaling Pathway Collagen Catabolic Process Zymogen Activation
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