CCL4L2 and VSIR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCL4L2	VSIR
Description		C-C motif chemokine ligand 4 like 2	V-set immunoregulatory receptor
Image		No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Membrane
	Molecular Function		Protein Binding Enzyme Binding Identical Protein Binding Endopeptidase Activator Activity
	Biological Process		Positive Regulation Of Gene Expression Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Zymogen Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Positive Regulation Of Collagen Catabolic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		G alpha (i) signalling events
Drugs
Diseases
GWAS		Body mass index ( 26426971) Protein quantitative trait loci ( 18464913)
Interacting Genes		33 interacting genes: AQP6 ARL13B CATSPER4 CERS4 CLRN1 COMT COQ9 CPLX4 CREB3L1 EBP ELOVL4 ERVFRD-1 FAM209A GET1 GPR152 GPR42 ITM2C JAGN1 MRM1 REEP4 RETREG3 SGPL1 SLC10A2 SLC18A1 SLC30A2 SLC61A1 SLC71A2 SLC7A1 SLC7A14 SSMEM1 TMEM179B TMEM51 VSIR	27 interacting genes: APOD ASGR1 ATP6V0C BMP10 C14orf180 CCL4L2 CLEC7A CLRN2 CNIH3 DOLK MS4A13 PLPP6 PLPPR2 PLSCR1 SLC35B1 SLC35B4 SMAD3 SMCO4 TMEM100 TMEM14C TMEM218 TMEM229B TMEM97 TNF TSPAN2 TSPO2 VAMP3
Entrez ID		9560	64115
HPRD ID		16030	15160
Ensembl ID		ENSG00000276070	ENSG00000107738
Uniprot IDs		Q8NHW4	Q9H7M9
PDB IDs			6MVL 6OIL 6U6V 8TBQ
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Norepinephrine Transport	Membrane Positive Regulation Of Neutrophil Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cholesterol Binding Plasma Membrane Regulation Of Wound Healing Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Production Regulation Of Neutrophil Activation Nucleotide-sugar Transmembrane Transport Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Response To Wounding Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Interleukin-1 Production Phosphatidate Phosphatase Activity Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Chemokine Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of MiRNA Transcription Positive Regulation Of Cartilage Development Regulation Of Interleukin-1 Production Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Activin Receptor Signaling Pathway Organophosphate Ester Transport Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Dolichol Kinase Activity Detection Of Yeast Detection Of Molecule Of Fungal Origin Phospholipid Dephosphorylation UDP-xylose Transmembrane Transport UDP-xylose Transmembrane Transporter Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy
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