PTGES and PTGER2

Number of citations of the paper that reports this interaction (PMID 8163486)
24

Data Source:
HPRD (in vivo)

		PTGES	PTGER2
Gene Name		prostaglandin E synthase	prostaglandin E receptor 2 (subtype EP2), 53kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Glutathione Binding Prostaglandin-E Synthase Activity	Prostaglandin E Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Proliferation Response To Organic Cyclic Compound Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Small Molecule Metabolic Process Response To Calcium Ion	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Cell Proliferation Cellular Response To Prostaglandin E Stimulus
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostanoid ligand receptors Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs			Alprostadil Dinoprostone Misoprostol
Diseases
GWAS
Protein-Protein Interactions		2 interactors: PTGER1 PTGER2	3 interactors: PTGDS PTGES PTGFR
Entrez ID		9536	5732
HPRD ID		05528	08905
Ensembl ID		ENSG00000148344	ENSG00000125384
Uniprot IDs		O14684	P43116
PDB IDs		3DWW 4AL0 4AL1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Response To Bacterium Regulation Of Integrin Activation Response To Other Organism Response To Biotic Stimulus Cellular Response To Prostaglandin E Stimulus Response To Lipid ERK1 And ERK2 Cascade Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Negative Regulation Of Leukocyte Migration T-helper Cell Differentiation G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Alpha-beta T Cell Differentiation Regulation Of Stress Fiber Assembly Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Response To Fatty Acid Response To External Stimulus Cellular Response To Mechanical Stimulus JNK Cascade Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Leukocyte Migration Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Protein Complex Assembly Regulation Of Cytokine Secretion Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger T Cell Differentiation Leukocyte Activation Involved In Immune Response Negative Regulation Of Secretion By Cell Cellular Response To Acid Chemical Negative Regulation Of Secretion Negative Regulation Of Protein Transport Positive Regulation Of Protein Secretion Negative Regulation Of Cell Migration	Cyclooxygenase Pathway Prostaglandin Biosynthetic Process Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Response To Lipid Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Lipopolysaccharide Fatty Acid Metabolic Process Response To Molecule Of Bacterial Origin Cellular Response To Prostaglandin D Stimulus Response To Bacterium Response To Organic Substance Calcium-mediated Signaling Using Intracellular Calcium Source Chronic Inflammatory Response Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Regulation Of Circadian Sleep/wake Cycle, Sleep Parturition Cellular Response To Prostaglandin Stimulus Response To Other Organism Response To Biotic Stimulus Response To Organic Cyclic Compound Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cellular Response To Fatty Acid Organic Acid Metabolic Process Lipid Metabolic Process Response To Fatty Acid Acute Inflammatory Response Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Circadian Rhythm Response To Calcium Ion Response To Retinoic Acid Response To External Stimulus Second-messenger-mediated Signaling Response To Glucocorticoid Response To Corticosteroid Cellular Response To Acid Chemical Regulation Of Behavior Small Molecule Metabolic Process
Tagcloud ?		acsf artificial avp balance cannulas cart cerebrospinal cerebroventricular circuits creb1 gabrd gip gipr gut hypothalami hypothalamic hypothalamus incretin insulinotrophic mapk1 microl neurocircuitry npy originally oxt polypeptide quantitatively taqman th	appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak
Tagcloud (Difference) ?		acsf artificial avp balance cannulas cart cerebrospinal cerebroventricular circuits creb1 gabrd gip gipr gut hypothalami hypothalamic hypothalamus incretin insulinotrophic mapk1 microl neurocircuitry npy originally oxt polypeptide quantitatively taqman th	appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak
Tagcloud (Intersection) ?