PTGES and PTGER1

Number of citations of the paper that reports this interaction (PMID 8253813)
40

Data Source:
HPRD (in vivo)

		PTGES	PTGER1
Gene Name		prostaglandin E synthase	prostaglandin E receptor 1 (subtype EP1), 42kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Glutathione Binding Prostaglandin-E Synthase Activity	Prostaglandin E Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Proliferation Response To Organic Cyclic Compound Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Small Molecule Metabolic Process Response To Calcium Ion	G-protein Coupled Receptor Signaling Pathway Response To Lipopolysaccharide
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Prostanoid ligand receptors GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs			Bupivacaine Carboprost Tromethamine Alprostadil Bimatoprost Dinoprostone Iloprost
Diseases
GWAS
Protein-Protein Interactions		2 interactors: PTGER1 PTGER2	5 interactors: ADRB2 PTGDS PTGER3 PTGES PTGFR
Entrez ID		9536	5731
HPRD ID		05528	08903
Ensembl ID		ENSG00000148344	ENSG00000160951
Uniprot IDs		O14684	P34995
PDB IDs		3DWW 4AL0 4AL1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Response To Bacterium Regulation Of Integrin Activation Response To Other Organism Response To Biotic Stimulus Cellular Response To Prostaglandin E Stimulus Response To Lipid ERK1 And ERK2 Cascade Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Negative Regulation Of Leukocyte Migration T-helper Cell Differentiation G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cytokine Secretion CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Alpha-beta T Cell Differentiation Regulation Of Stress Fiber Assembly Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Response To Fatty Acid Response To External Stimulus Cellular Response To Mechanical Stimulus JNK Cascade Positive Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Leukocyte Migration Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Protein Complex Assembly Regulation Of Cytokine Secretion Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger T Cell Differentiation Leukocyte Activation Involved In Immune Response Negative Regulation Of Secretion By Cell Cellular Response To Acid Chemical Negative Regulation Of Secretion Negative Regulation Of Protein Transport Positive Regulation Of Protein Secretion Negative Regulation Of Cell Migration	Heat Generation Cyclooxygenase Pathway Response To Lipid Prostaglandin Biosynthetic Process Temperature Homeostasis Prostaglandin Metabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Response To Bacterium Acute Inflammatory Response Icosanoid Metabolic Process Response To External Stimulus Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Response To Other Organism Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Biotic Stimulus Fatty Acid Biosynthetic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Response To Organic Substance Fever Generation Multicellular Organismal Homeostasis G-protein Coupled Receptor Signaling Pathway Cellular Response To Prostaglandin D Stimulus Diet Induced Thermogenesis Fatty Acid Metabolic Process Positive Regulation Of Fever Generation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Fever Generation Positive Regulation Of Heat Generation Calcium-mediated Signaling Using Intracellular Calcium Source Chronic Inflammatory Response Inflammatory Response Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Urine Volume Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Dietary Excess Parturition Cellular Response To Prostaglandin Stimulus Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Response To Stimulus
Tagcloud ?		acsf artificial avp balance cannulas cart cerebrospinal cerebroventricular circuits creb1 gabrd gip gipr gut hypothalami hypothalamic hypothalamus incretin insulinotrophic mapk1 microl neurocircuitry npy originally oxt polypeptide quantitatively taqman th	acutely autacoids bdkrb2 bks blots butaprost composing counterpart cyclooxygenases deferens epididymal epithelia hoe140 lining lysylbradykinin prostaglandin prostaglandins ptgs ptgs1 ptgs2 ptgss pvd9902 reportedly sc sulprostone vas
Tagcloud (Difference) ?		acsf artificial avp balance cannulas cart cerebrospinal cerebroventricular circuits creb1 gabrd gip gipr gut hypothalami hypothalamic hypothalamus incretin insulinotrophic mapk1 microl neurocircuitry npy originally oxt polypeptide quantitatively taqman th	acutely autacoids bdkrb2 bks blots butaprost composing counterpart cyclooxygenases deferens epididymal epithelia hoe140 lining lysylbradykinin prostaglandin prostaglandins ptgs ptgs1 ptgs2 ptgss pvd9902 reportedly sc sulprostone vas
Tagcloud (Intersection) ?