GOSR1 and SNAP25

Number of citations of the paper that reports this interaction (PMID 9325254)
12

Data Source:
BioGRID (pull down)

		GOSR1	SNAP25
Gene Name		golgi SNAP receptor complex member 1	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Integral Component Of Membrane SNARE Complex	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function	SNAP Receptor Activity	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Protein Transport Retrograde Transport, Endosome To Golgi	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways			Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		8 interactors: APP EBI3 GABARAPL2 NAPA NSF SNAP25 STX5 USO1	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		9527	6616
HPRD ID		04936	02637
Ensembl ID		ENSG00000108587	ENSG00000132639
Uniprot IDs		E9PCW1 O95249	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Membrane Fusion Golgi Vesicle Transport Vesicle Docking Membrane Docking Vesicle-mediated Transport Membrane Organization Golgi Vesicle Docking Establishment Of Localization In Cell Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Cellular Localization Organelle Fusion Intracellular Transport Vesicle Fusion With Golgi Apparatus Protein Transport Vesicle Organization Establishment Of Protein Localization Organelle Disassembly Transport Intracellular Protein Transport Exocytosis Protein Localization Post-Golgi Vesicle-mediated Transport ER To Golgi Vesicle-mediated Transport Secretion By Cell Cellular Protein Localization Synaptic Growth At Neuromuscular Junction SNARE Complex Disassembly Synaptic Transmission Secretion Regulation Of Secretion Collateral Sprouting In Absence Of Injury Golgi Disassembly Regulation Of Exocytosis Cytoplasmic Transport Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Vesicle Priming Axon Choice Point Recognition Positive Regulation Of Metabolic Process Regulation Of Golgi Organization Golgi Inheritance Cell-cell Signaling Synaptic Vesicle Docking Neuron Remodeling Synaptic Vesicle Priming Early Endosome To Golgi Transport Cell Communication Regulation Of Protein Metabolic Process	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?			anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?			anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?