PMPCB and FXN

Number of citations of the paper that reports this interaction (PubMedID 9700204)
0

Data Source:
HPRD (two hybrid, in vitro)

		PMPCB	FXN
Description		peptidase, mitochondrial processing subunit beta	frataxin
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Processing Peptidase Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Ferroxidase Activity Protein Binding Enzyme Activator Activity Ferrous Iron Binding Ferric Iron Binding Oxidoreductase Activity Iron Chaperone Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport	Oxidative Phosphorylation Heme Biosynthetic Process Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Iron-sulfur Cluster Assembly Protein Autoprocessing Proprioception Intracellular Monoatomic Cation Homeostasis Mitochondrial Respiratory Chain Complex III Assembly Organ Growth Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Negative Regulation Of Organ Growth Muscle Cell Cellular Homeostasis Positive Regulation Of Lyase Activity Protein Maturation Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Inorganic Ion Homeostasis
Pathways		Mitochondrial protein import Processing of SMDT1	Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis Maturation of TCA enzymes and regulation of TCA cycle Complex III assembly
Drugs			Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases			Friedreich ataxia
GWAS		Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847)	Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)
Interacting Genes		5 interacting genes: FXN MARK3 NPSR1 PMPCA PTGER4	7 interacting genes: ACTN1 AKT1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126
Entrez ID		9512	2395
HPRD ID		07539	06013
Ensembl ID		ENSG00000105819	ENSG00000165060
Uniprot IDs		A0A9L9PXG6 A0A9L9PXH0 A0A9L9PXI7 B3KM34 G3V0E4 O75439 Q96CP5	A0A0S2Z3G4 Q16595
PDB IDs			1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU 8PK8 8PK9 8RME
Enriched GO Terms of Interacting Partners?			Protein K29-linked Ubiquitination Mitochondrial Calcium Ion Transmembrane Transport Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Postsynapse Organization Platelet Morphogenesis Structural Constituent Of Postsynapse Protein Modification Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Protein Metabolic Process Protein Maturation Mammalian Oogenesis Stage Regulation Of Ketone Metabolic Process Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Small Molecule Metabolic Process TRNA (guanine-N7)-methylation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process TORC2 Complex Binding Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of TRNA Methylation Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Steroid Metabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Phospholipid Binding Membrane Curvature Sensor Activity Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Processing Peptidase Complex Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control Cellular Response To Decreased Oxygen Levels Actin Filament Binding Fascia Adherens Actin Filament Network Formation Response To Rapamycin Cellular Response To Oxygen Levels Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Calcium Ion Transmembrane Transport Negative Regulation Of Fatty Acid Beta-oxidation
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