NAPSA and LCE1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NAPSA	LCE1B
Description		napsin A aspartic peptidase	late cornified envelope 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Extracellular Exosome Alveolar Lamellar Body Multivesicular Body Lumen
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Membrane Protein Proteolysis Surfactant Homeostasis	Epidermis Development Keratinization
Pathways		Surfactant metabolism	Formation of the cornified envelope
Drugs
Diseases
GWAS			Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		1 interacting genes: LCE1B	82 interacting genes: ADAMTSL4 ALPP BEND5 CATSPER1 CHIC2 CYSRT1 FBLN1 FUCA2 GRN HOXA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MDFI MEOX2 NAPSA NBPF19 NOTCH2NLA NUFIP2 OTX1 P4HB RGS17 RGS20 RNF4 SMCP SPRY1 SPRY2 SPRY3 TGM1 TRIM42 VASN
Entrez ID		9476	353132
HPRD ID		07064	17259
Ensembl ID		ENSG00000131400	ENSG00000196734
Uniprot IDs		M0QXC5 O96009	Q5T7P3
PDB IDs
Enriched GO Terms of Interacting Partners?		PTB Domain Binding Nuclear Pore Central Transport Channel Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome Mitotic Centrosome Separation Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Centriole Replication Centrosome Separation Regulation Of Mitotic Cytokinesis Regulation Of Protein Localization To Centrosome Signaling Receptor Complex Adaptor Activity Flemming Body Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Spindle Organization Regulation Of Centrosome Duplication Centrosome Cycle SH2 Domain Binding Negative Regulation Of ERBB Signaling Pathway Centriole Assembly Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cytokinesis Regulation Of Centriole Replication Positive Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Hsp90 Protein Binding Structural Constituent Of Nuclear Pore Hsp70 Protein Binding Negative Regulation Of Ras Protein Signal Transduction Mitotic Metaphase Chromosome Alignment Metaphase Chromosome Alignment Regulation Of Centrosome Cycle Negative Regulation Of Small GTPase Mediated Signal Transduction Cellular Senescence Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Keratinization Regulation Of ERBB Signaling Pathway RNA Export From Nucleus Chromosome Localization Microtubule Organizing Center Organization Nuclear Pore Regulation Of Cytokinesis Positive Regulation Of Cell Division Positive Regulation Of Organelle Assembly Ubiquitin Binding Phospholipid Binding Nuclear Export Import Into Nucleus Regulation Of Mitotic Nuclear Division MRNA Transport	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Cytosol Protein Binding Identical Protein Binding Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Ras Protein Signal Transduction Microtubule End Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Lens Fiber Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway
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