SAG and CHRM2

Number of citations of the paper that reports this interaction (PMID 10952973)
5

Data Source:
HPRD (in vivo)

		SAG	CHRM2
Gene Name		S-antigen; retina and pineal gland (arrestin)	cholinergic receptor, muscarinic 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Postsynaptic Membrane
	Molecular Function	Opsin Binding Protein Phosphatase Inhibitor Activity Phosphoprotein Binding	G-protein Coupled Acetylcholine Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Regulation Of Heart Contraction Response To Virus Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway
Pathways		Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Carbachol Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxacurium chloride Doxepin Flavoxate Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Fesoterodine Dimethindene Aclidinium
Diseases
GWAS		Calcium levels ( 20705733) Crohn's disease ( 22412388)	Heart rate ( 23583979)
Protein-Protein Interactions		3 interactors: ADRA1B CHRM2 RHO	9 interactors: GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 SAG SET
Entrez ID		6295	1129
HPRD ID		01625	00328
Ensembl ID		ENSG00000130561	ENSG00000181072
Uniprot IDs		A0FDN6 B7Z7L5 P10523	A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1
PDB IDs			1LUB 3UON
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Red, Far-red Light Phototransduction Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Regulation Of Heart Contraction Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Light Stimulus Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Radiation Regulation Of Glycogen Catabolic Process Positive Regulation Of Systemic Arterial Blood Pressure Behavioral Response To Cocaine Protein-chromophore Linkage G-protein Coupled Acetylcholine Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Adult Heart Development Cell Surface Receptor Signaling Pathway Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Heart Contraction Rhodopsin Mediated Signaling Pathway Chemical Homeostasis Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of Glucose Metabolic Process Response To Amphetamine Cell-cell Signaling Positive Regulation Of Blood Pressure Regulation Of Glycogen Metabolic Process Response To Morphine System Development Blood Vessel Remodeling Response To Abiotic Stimulus Response To Cocaine Response To Amine Neurological System Process Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Visual Learning Multicellular Organismal Development Visual Behavior	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Dopamine Receptor Signaling Pathway Platelet Activation G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Tachykinin Receptor Signaling Pathway Signaling Negative Regulation Of Cell Death Protein Neddylation Cell Communication Regulation Of Cellular Process Regulation Of Melanocyte Differentiation Cellular Response To Prostaglandin E Stimulus Response To Redox State G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Response To PH Nucleosome Disassembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Receptor Catabolic Process Negative Regulation Of Histone Acetylation Cellular Response To Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Developmental Pigmentation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Protein Acetylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Apoptotic Process Endosome To Lysosome Transport Rhodopsin Mediated Signaling Pathway Regulation Of Cell Death
Tagcloud ?		33p 35s abundantly anchor anchored antigenic cilia ciliary detergent devoid ethanolamine glycosylphosphatidylinositol gpi labeling moiety named paramecium partitioning phosphatidylinositol phospholipase phosphoric primaurelia sgp1 sgp2 sgp3 sgps triton unreduced weights	adulthood amplitude auditory childhood cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual
Tagcloud (Difference) ?		33p 35s abundantly anchor anchored antigenic cilia ciliary detergent devoid ethanolamine glycosylphosphatidylinositol gpi labeling moiety named paramecium partitioning phosphatidylinositol phospholipase phosphoric primaurelia sgp1 sgp2 sgp3 sgps triton unreduced weights	adulthood amplitude auditory childhood cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual
Tagcloud (Intersection) ?