SAG and ADRA1B

Number of citations of the paper that reports this interaction (PMID 8617782)
24

Data Source:
HPRD (in vivo)

		SAG	ADRA1B
Gene Name		S-antigen; retina and pineal gland (arrestin)	adrenoceptor alpha 1B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytosol	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane
	Molecular Function	Opsin Binding Protein Phosphatase Inhibitor Activity Phosphoprotein Binding	Alpha1-adrenergic Receptor Activity Protein Heterodimerization Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity	Blood Vessel Remodeling Response To Amphetamine Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Adult Heart Development Locomotory Behavior Cell Proliferation Visual Learning Cell Growth Regulation Of Vasoconstriction Organ Growth Intracellular Signal Transduction Glucose Homeostasis Response To Morphine Positive Regulation Of MAPK Cascade Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycogen Catabolic Process Behavioral Response To Cocaine Regulation Of Cardiac Muscle Contraction Adrenergic Receptor Signaling Pathway
Pathways		Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Adrenoceptors G alpha (12/13) signalling events
Drugs			Midodrine Ziprasidone Dapiprazole Olanzapine Alfuzosin Clozapine Norepinephrine Phenylephrine Promazine Prazosin Chlorpromazine Doxazosin Labetalol Nicardipine Epinephrine Thioridazine Ergotamine Tamsulosin Methoxamine Trimipramine Risperidone Modafinil Propiomazine Doxepin Nefazodone Terazosin Pergolide Bromocriptine Quetiapine Aripiprazole Lisdexamfetamine Paliperidone Methotrimeprazine Dextroamphetamine Phendimetrazine Propericiazine Acepromazine Thioproperazine Dronedarone Sertindole Silodosin Droxidopa Xylometazoline
Diseases
GWAS		Calcium levels ( 20705733) Crohn's disease ( 22412388)
Protein-Protein Interactions		3 interactors: ADRA1B CHRM2 RHO	11 interactors: ADRA1A AP2M1 EZR FLNC GNA11 GNAQ NOS1 PPP1R9B PRKCA SAG STAT1
Entrez ID		6295	147
HPRD ID		01625	00080
Ensembl ID		ENSG00000130561
Uniprot IDs		A0FDN6 B7Z7L5 P10523	P35368
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Red, Far-red Light Phototransduction Vasoconstriction Of Artery Involved In Baroreceptor Response To Lowering Of Systemic Arterial Blood Pressure Regulation Of Heart Contraction Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Light Stimulus Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of The Force Of Heart Contraction By Chemical Signal Response To Radiation Regulation Of Glycogen Catabolic Process Positive Regulation Of Systemic Arterial Blood Pressure Behavioral Response To Cocaine Protein-chromophore Linkage G-protein Coupled Acetylcholine Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Adult Heart Development Cell Surface Receptor Signaling Pathway Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Heart Contraction Rhodopsin Mediated Signaling Pathway Chemical Homeostasis Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of Glucose Metabolic Process Response To Amphetamine Cell-cell Signaling Positive Regulation Of Blood Pressure Regulation Of Glycogen Metabolic Process Response To Morphine System Development Blood Vessel Remodeling Response To Abiotic Stimulus Response To Cocaine Response To Amine Neurological System Process Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Visual Learning Multicellular Organismal Development Visual Behavior	Regulation Of The Force Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To External Stimulus Developmental Process Positive Regulation Of Phospholipase Activity Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Melanocyte Differentiation Negative Regulation Of Catalytic Activity Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Filopodium Assembly Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signal Transduction Regulation Of Muscle Contraction Regulation Of Developmental Pigmentation Regulation Of Heart Contraction Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Intracellular Signal Transduction Signaling Platelet Activation Rhodopsin Mediated Signaling Pathway System Development Cell Communication G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Negative Regulation Of Signaling Wound Healing Dopamine Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Locomotion Response To Stimulus Response To Wounding Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Multicellular Organismal Development Regulation Of Catalytic Activity Cellular Response To Stimulus
Tagcloud ?		33p 35s abundantly anchor anchored antigenic cilia ciliary detergent devoid ethanolamine glycosylphosphatidylinositol gpi labeling moiety named paramecium partitioning phosphatidylinositol phospholipase phosphoric primaurelia sgp1 sgp2 sgp3 sgps triton unreduced weights	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Difference) ?		33p 35s abundantly anchor anchored antigenic cilia ciliary detergent devoid ethanolamine glycosylphosphatidylinositol gpi labeling moiety named paramecium partitioning phosphatidylinositol phospholipase phosphoric primaurelia sgp1 sgp2 sgp3 sgps triton unreduced weights	adrenergic agonists angiogenesis biodistribution chemokine cognate cxcr1 distributed gpcr gpcrs hemostasis intractable lipidated loops par1 pathophysiological penetrating pepducins pharmacodynamic pharmacokinetic pharmacology possess protease s1p3 sepsis sphingosine superfamily thrombosis vital
Tagcloud (Intersection) ?