MED27 and AFP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MED27	AFP
Description		mediator complex subunit 27	alpha fetoprotein
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Mediator Complex Core Mediator Complex	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen
	Molecular Function	Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Small Molecule Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Ovulation From Ovarian Follicle Apoptotic Process Immune Response Sexual Reproduction Response To Nutrient Levels Progesterone Metabolic Process Homeostasis Of Number Of Cells
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Gout (normal type) ( 32238385) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Interacting Genes		12 interacting genes: AFP ARFGAP1 CEBPA ESR1 FBXO7 MED19 MED22 MED30 MED8 MED9 RBPJ SOX5	14 interacting genes: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP
Entrez ID		9442	174
HPRD ID		05438	00074
Ensembl ID		ENSG00000160563	ENSG00000081051
Uniprot IDs		Q6P2C8	P02771
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	3MRK 7RE7 7RE8 7YIM 8X1N
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Regulation Of DNA-templated Transcription Initiation Mediator Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein-DNA Complex Assembly Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Ligase Complex Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stem Cell Proliferation Protein-containing Complex Organization Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ovulation Cycle Process Steroid Metabolic Process Transcription Regulator Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Gene Expression Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Somatic Stem Cell Population Maintenance Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process	Intracellular Signal Transduction Regulation Of Protein Stability Cell Death Apoptotic Process Programmed Cell Death Endopeptidase Activity Rhythmic Process Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Cytoplasm Death Receptor Binding Negative Regulation Of Cellular Senescence Execution Phase Of Apoptosis Response To UV DNA Damage Response Regulation Of Myeloid Cell Apoptotic Process Protein Acetylation Innate Immune Response-activating Signaling Pathway Post-translational Protein Modification Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity Protein Stabilization Protein Modification Process Positive Regulation Of Protein Linear Polyubiquitination Response To Stress Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Response To Hypoxia Phospholipase A2 Activator Activity Chemokine (C-C Motif) Ligand 5 Binding P53 Binding
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