MED27 and AFP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MED27	AFP
Gene Name		mediator complex subunit 27	alpha-fetoprotein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Mediator Complex	Extracellular Space Cytoplasm
	Molecular Function	Transcription Coactivator Activity Protein Binding	Metal Ion Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process SMAD Protein Signal Transduction
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Protein-Protein Interactions		9 interactors: AFP ARFGAP1 MED19 MED22 MED30 MED8 MED9 RBPJ SOX5	10 interactors: AP4S1 CCR5 EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 SGSM2 XIAP
Entrez ID		9442	174
HPRD ID		05438	00074
Ensembl ID		ENSG00000160563	ENSG00000081051
Uniprot IDs		Q6P2C8	P02771
PDB IDs			3MRK
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Epidermal Cell Fate Specification Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Blood Vessel Lumenization Blood Vessel Endothelial Cell Fate Specification Nitrogen Compound Metabolic Process Protein Secretion Endothelial Cell Fate Specification Stem Cell Maintenance Clara Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation Interleukin-4 Secretion Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Cellular Process Hair Follicle Maturation Regulation Of Timing Of Neuron Differentiation Auditory Receptor Cell Fate Commitment Dorsal Aorta Morphogenesis Arterial Endothelial Cell Differentiation Regulation Of Mesenchymal Stem Cell Differentiation Dorsal Aorta Development Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Endocardium Morphogenesis Endothelial Tube Morphogenesis	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Signal Transduction Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Programmed Cell Death Regulation Of Signaling Cell Death Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Metal Ion Homeostasis Positive Regulation Of Protein Linear Polyubiquitination Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Late Endosome To Golgi Transport Ion Homeostasis Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Mitotic Cell Cycle Checkpoint Regulation Of Proteolysis Mammary Gland Branching Involved In Thelarche Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Cytosolic Calcium Ion Homeostasis Cardiac Muscle Cell Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Cell Apoptotic Process Regulation Of Protein Ubiquitination Endosomal Transport Regulation Of Cysteine-type Endopeptidase Activity Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?			acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Difference) ?			acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Intersection) ?