MED27

Description		mediator complex subunit 27
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Gout (normal type) ( 32238385) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: AFP ARFGAP1 CEBPA ESR1 FBXO7 MED19 MED22 MED30 MED8 MED9 RBPJ SOX5
Entrez ID		9442
HPRD ID		05438
Ensembl ID		ENSG00000160563
Uniprot IDs		Q6P2C8
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Preinitiation Complex Assembly Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Regulation Of DNA-templated Transcription Initiation Mediator Complex Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein-DNA Complex Assembly Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Ligase Complex Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Stem Cell Proliferation Protein-containing Complex Organization Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ovulation Cycle Process Steroid Metabolic Process Transcription Regulator Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Gene Expression Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Somatic Stem Cell Population Maintenance Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process
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