CD86 and P4HA2

Data Source: HiPPIP (Novel)

		CD86	P4HA2
Name		CD86 molecule	prolyl 4-hydroxylase subunit alpha 2
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Centriolar Satellite Extracellular Exosome	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity Receptor Ligand Activity	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of DNA-templated Transcription Lymphocyte Activation Symbiont Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	None
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Collagen biosynthesis and modifying enzymes
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1	Proline
GWAS		Autoimmune thyroid disease ( 32581359 ) Diffuse large B cell lymphoma ( 25261932 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Follicular lymphoma ( 25279986 ) Gut microbiota (functional units) ( 27694959 ) Multiple sclerosis ( 21833088 22190364 24076602 27386562 31604244 ) Selective IgA deficiency ( 27723758 ) Systemic lupus erythematosus ( 19838195 ) Type 2 diabetes ( 30718926 )	Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 22412388 28067908 ) Giant cell arteritis ( 28041642 ) Height ( 28552196 ) Inflammatory bowel disease ( 28067908 ) Intracranial aneurysm ( 33199917 ) Intraocular pressure ( 29617998 ) Subcortical volume (MOSTest) ( 32665545 ) Sum eosinophil basophil counts ( 27863252 ) Ulcerative colitis ( 28067908 ) Youthful appearance (self-reported) ( 32339537 )
Novel Interactors		9 novel interactors: CSTA FXR1 INHBA KPNA1 MCM2 P4HA2 TEX55 TRA2A TRH	2 novel interactors: CD86 PRKAR2A
Interacting Genes		6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1	7 interacting genes: CLNK CREB3 FHL3 OGT P4HB PRRC2A TNS4
Entrez ID		942	8974
HPRD ID		03011	11862
Ensembl ID		ENSG00000114013	ENSG00000072682
Uniprot IDs		A0A0X9R4E0 A8K632 P42081	O15460 Q05DA4
PDB IDs		1I85 1NCN 5YXK 8FXX 8FXY 8HXB 8HXC	6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC
GO Terms Enriched among Interactors		Protein Complex Involved In Cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of DNA Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Aldosterone NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Mineralocorticoid Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Circadian Sleep/wake Cycle NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Regulation Of T Cell Proliferation Regulation Of B Cell Activation Regulation Of Cell Development Regulation Of Regulatory T Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Differentiation Negative Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Negative Regulation Of B Cell Activation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Thyrotropin-releasing Hormone Activity Negative Regulation Of Immune System Process Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Myofibroblast Differentiation Regulation Of Cell Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Inhibin A Complex Positive Regulation Of Ovulation Progesterone Secretion Positive Regulation Of DNA Recombination Regulation Of Behavior Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation	Focal Adhesion