CD86 and CSTA

		CD86	CSTA
Description		CD86 molecule	cystatin A
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Centriolar Satellite Extracellular Exosome	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol Peptidase Inhibitor Complex
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity Receptor Ligand Activity	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of DNA-templated Transcription Lymphocyte Activation Symbiont Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Formation of the cornified envelope
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 21833088 22190364 24076602 27386562 31604244) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)	Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 25972035 29403010)
Interacting Genes		6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1	12 interacting genes: CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17
Entrez ID		942	1475
HPRD ID		03011	01697
Ensembl ID		ENSG00000114013	ENSG00000121552
Uniprot IDs		A0A0X9R4E0 A8K632 P42081	P01040
PDB IDs		1I85 1NCN 5YXK 8FXX 8FXY 8HXB 8HXC	1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE 8GT0 8GT7
Enriched GO Terms of Interacting Partners?		Protein Complex Involved In Cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of DNA Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Aldosterone NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Mineralocorticoid Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Circadian Sleep/wake Cycle NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Regulation Of T Cell Proliferation Regulation Of B Cell Activation Regulation Of Cell Development Regulation Of Regulatory T Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Differentiation Negative Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Negative Regulation Of B Cell Activation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Thyrotropin-releasing Hormone Activity Negative Regulation Of Immune System Process Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Myofibroblast Differentiation Regulation Of Cell Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Inhibin A Complex Positive Regulation Of Ovulation Progesterone Secretion Positive Regulation Of DNA Recombination Regulation Of Behavior Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation	Peptide Cross-linking Cornified Envelope Cellular Response To Thyroid Hormone Stimulus Keratinization Response To Thyroid Hormone Cysteine-type Peptidase Activity Protein Metabolic Process Endolysosome Lumen Structural Constituent Of Skin Epidermis Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Proteoglycan Binding Epidermal Cell Differentiation Protein Modification Process Symbiont Entry Into Host Cell Ficolin-1-rich Granule Lumen Decidualization Epithelial Cell Differentiation Biological Process Involved In Interaction With Host Extracellular Matrix Peptidase Activity Extracellular Exosome Collagen Catabolic Process Macromolecule Metabolic Process Extracellular Space Zymogen Activation Endopeptidase Inhibitor Activity Developmental Process HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Perforant Pathway To Dendrate Granule Cell Synapse Collagen Binding Collagen Metabolic Process Immune Response Adaptive Immune Response Immune System Process Proteolysis Involved In Protein Catabolic Process Kininogen Binding Enkephalin Processing Copulation Dendrite Regeneration Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Tissue Development Positive Regulation Of Lymphotoxin A Production Endopeptidase Activity Cellular Response To Hormone Stimulus Response To Odorant
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