CD86 and TEX55

		CD86	TEX55
Description		CD86 molecule	testis expressed 55
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Centriolar Satellite Extracellular Exosome	Nucleus Cilium Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity Receptor Ligand Activity	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of DNA-templated Transcription Lymphocyte Activation Symbiont Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 21833088 22190364 24076602 27386562 31604244) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		942	152405
HPRD ID		03011	08146
Ensembl ID		ENSG00000114013	ENSG00000163424
Uniprot IDs		A0A0X9R4E0 A8K632 P42081	Q96M34
PDB IDs		1I85 1NCN 5YXK 8FXX 8FXY 8HXB 8HXC
Enriched GO Terms of Interacting Partners?		Protein Complex Involved In Cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of DNA Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Aldosterone NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Mineralocorticoid Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Circadian Sleep/wake Cycle NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Regulation Of T Cell Proliferation Regulation Of B Cell Activation Regulation Of Cell Development Regulation Of Regulatory T Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Differentiation Negative Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Negative Regulation Of B Cell Activation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Thyrotropin-releasing Hormone Activity Negative Regulation Of Immune System Process Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Myofibroblast Differentiation Regulation Of Cell Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Inhibin A Complex Positive Regulation Of Ovulation Progesterone Secretion Positive Regulation Of DNA Recombination Regulation Of Behavior Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation	Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of Interleukin-4 Production T Cell Costimulation Regulation Of Interleukin-2 Production Coreceptor Activity Regulation Of Interleukin-4 Production Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Type 2 Immune Response Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of T-helper Cell Differentiation Negative Regulation Of T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Virus Receptor Activity Regulation Of Immunoglobulin Production Positive Regulation Of Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Symbiont Entry Into Host Cell Positive Regulation Of Lymphocyte Differentiation Centriolar Satellite Receptor Ligand Activity Negative Regulation Of T Cell Activation Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Lymphocyte Activation Positive Regulation Of Lymphocyte Proliferation Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Mononuclear Cell Proliferation Cellular Response To Molecule Of Bacterial Origin B Cell Activation Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Biological Process Involved In Interaction With Host Negative Regulation Of Leukocyte Activation Regulation Of T Cell Differentiation
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